Gene: Txnip
Official Full Name: thioredoxin interacting proteinprovided by MGI
Gene Summary: Enables enzyme inhibitor activity. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; platelet-derived growth factor receptor signaling pathway; and protein import into nucleus. Located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Reye syndrome and hepatocellular carcinoma. Orthologous to human TXNIP (thioredoxin interacting protein). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01065 | Txnip Knockout cell line (RAW264.7) | Mouse | Txnip | Negative | Online Inquiry |
Txnip Gene Knockout Cell Lines are specialized cell lines engineered to lack the Thioredoxin-interacting protein (Txnip), a critical regulator of redox homeostasis and cellular metabolism. This gene knockout allows researchers to elucidate the biological roles of Txnip, particularly in contexts related to oxidative stress, inflammation, and metabolic diseases. Txnip is known to interact with thioredoxin and modulates various signaling pathways, making it an intriguing target for understanding pathological conditions.
The primary function of the Txnip knockout cell lines is to create a controlled environment where the effects of Txnip deficiency can be studied in detail. By removing Txnip, these cell lines enable the investigation of cellular mechanisms under oxidative stress, as well as the consequent metabolic adaptations. This can be particularly useful in the study of diseases such as diabetes, cancer, and neurodegeneration where metabolic dysregulation is prevalent. The Txnip knockout cell lines provide a robust platform to explore these pathways and identify potential therapeutic targets.
In scientific research, these cell lines are invaluable for developing novel interventions and therapies that manipulate redox states within cells. They serve as models for evaluating drug responses and the underlying mechanisms of disease, paving the way for advancements in personalized medicine and targeted therapy.
Compared to traditional methods of gene manipulation, our Txnip Gene Knockout Cell Lines ensure higher efficiency and specificity in targeting the Txnip gene, reducing off-target effects that can confound experimental results. This clarity in research is essential for producing reliable data that can contribute to scientific knowledge and clinical applications.
For researchers and clinicians aiming to deepen their understanding of oxidative stress and its implications, our Txnip Gene Knockout Cell Lines represent an essential resource. The reliable performance and well-documented background of these cell lines facilitate rigorous scientific inquiry, supporting the advancement of knowledge across multiple biomedical disciplines.
We pride ourselves on our expertise in developing and providing high-quality biological products that meet the evolving needs of the research community, ensuring that you have the tools necessary to drive your scientific discovery forward.
Please note that all services are for research use only. Not intended for any clinical use.
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