Gene: Trib1
Official Full Name: tribbles pseudokinase 1provided by MGI
Gene Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity; ubiquitin protein ligase binding activity; and ubiquitin-protein transferase regulator activity. Involved in several processes, including negative regulation of DNA-binding transcription factor activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; and regulation of myeloid leukocyte differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and submandibular gland primordium. Orthologous to human TRIB1 (tribbles pseudokinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01090 | Trib1 Knockout cell line (C2C12) | Mouse | Trib1 | 1:3~1:4 | Negative | Online Inquiry |
Trib1 Gene Knockout Cell Lines are strategically engineered cellular models that have undergone targeted gene disruption of the Tribbles homolog 1 (Trib1) gene. These cell lines serve as a valuable resource for researchers investigating the functional implications of Trib1 in various biological processes, particularly those related to metabolism, cell signaling, and immune response. By creating a knockout of the Trib1 gene, scientists can elucidate the specific roles of this gene in physiological and pathological contexts, thereby advancing our understanding of its impact on disease mechanisms.
The Trib1 protein functions as an important regulator in several cellular pathways, particularly those tied to lipid metabolism and inflammation. By inhibiting its expression through gene knockout, researchers can explore the downstream effects on cellular proliferation, differentiation, and the response to external stimuli. Utilizing these knockout cell lines allows for controlled experimentation, revealing critical insights into the Trib1-mediated regulatory networks and pathway interactions.
The scientific relevance of Trib1 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They are instrumental in studies exploring metabolic disorders such as obesity and diabetes, as well as inflammatory diseases. By facilitating the identification of novel therapeutic targets, these cell lines contribute to the development of innovative treatment modalities, enhancing translational research efforts.
Compared to alternative models, such as wild-type cell lines or overexpression systems, knockout models provide a clearer understanding of gene function by eliminating its activity altogether. This specificity allows for more accurate interpretation of experimental outcomes and often leads to more reproducible results, a crucial aspect of successful scientific inquiry.
For researchers and clinicians, the Trib1 Gene Knockout Cell Lines are an essential tool, offering a robust platform for dissecting the complex role of the Trib1 gene in health and disease. By using these models, scientists can streamline their research efforts and accelerate the discovery of novel insights that could translate into therapeutic advancements.
As a leader in producing high-quality biological research tools, our company is dedicated to providing innovative solutions that enhance scientific progress and open new avenues for discovery. Our expertise in genetic engineering and cell line development ensures that researchers have access to accurate, reliable models crucial for their studies.
Please note that all services are for research use only. Not intended for any clinical use.
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