Gene: TNFRSF1B
Official Full Name: TNF receptor superfamily member 1Bprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01221 | Tnfrsf1b Knockout cell line(4T1) | Mouse | Tnfrsf1b | 1:3~1:4 | Negative | Online Inquiry |
KO01222 | Tnfrsf1b Knockout cell line(CT26.WT) | Mouse | Tnfrsf1b | 1:3~1:4 | Negative | Online Inquiry |
KO01223 | Tnfrsf1b Knockout cell line(MC38) | Mouse | Tnfrsf1b | 1:2-1:4 | Negative | Online Inquiry |
TNFRSF1B Gene Knockout Cell Lines are genetically engineered cell populations designed to specifically lack the TNFRSF1B gene, which encodes the type II tumor necrosis factor receptor (TNF receptor superfamily member 1B). This advanced tool allows researchers to study the functional consequences of TNFRSF1B deficiency, thereby elucidating its role in various physiological and pathological processes.
The primary function of these knockout cell lines is to serve as a model to investigate the signaling pathways mediated by TNFRSF1B, which has been implicated in immune regulation, apoptosis, and inflammatory responses. By employing these cell lines, researchers can analyze the effects of TNF signaling on cell proliferation, survival, and differentiation. This is particularly important in the context of autoimmune diseases, cancer, and other conditions where TNF signaling plays a critical role.
The scientific importance of TNFRSF1B Gene Knockout Cell Lines extends to both basic research and clinical applications. In laboratory settings, they are indispensable for dissecting the molecular mechanisms of TNF-mediated actions and can be utilized in drug discovery, allowing for the screening of therapeutic agents targeting TNF pathways. Clinically, insights gained from these studies could lead to the development of novel treatments for diseases marked by aberrant TNF signaling.
One of the key advantages of our TNFRSF1B Gene Knockout Cell Lines is their high specificity and reliability, created through rigorous gene-editing techniques that ensure efficient and precise knockout of the target gene. Unlike traditional RNA interference methods, these knockout lines provide a more permanent and consistent model with fewer off-target effects, thus enhancing the reproducibility of research findings.
In addition, our product comes with extensive technical support and documentation, empowering researchers to optimize their experimental design effectively. With a commitment to delivering high-quality biological products, our company stands out in the market, backed by a team of experts skilled in genetic engineering and cell line development. This expertise ensures that we provide not just products but solutions that drive innovation and improve outcomes in both research and clinical settings.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.