Gene: Tnfrsf17
Official Full Name: tumor necrosis factor receptor superfamily, member 17provided by MGI
Gene Summary: Predicted to enable signaling receptor activity. Acts upstream of or within lymphocyte homeostasis. Predicted to be located in membrane. Is expressed in several structures, including hemolymphoid system gland; hippocampus; male reproductive gland or organ; superior cervical ganglion; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma and multiple myeloma. Orthologous to human TNFRSF17 (TNF receptor superfamily member 17). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00816 | Tnfrsf17 Knockout cell line (MC38) | Mouse | Tnfrsf17 | 1:2-1:4 | Negative | Online Inquiry |
Tnfrsf17 Gene Knockout Cell Lines represent a specialized and innovative tool in molecular biology, designed to aid researchers in dissecting the functional roles of the Tnfrsf17 gene, also known as BAFF receptor (B-cell activating factor receptor). These cell lines have been genetically engineered to lack the Tnfrsf17 gene, providing a robust platform for studying its impact on B-cell biology, signaling pathways, and immune responses. By enabling precise manipulation of genetic material, these knockout models offer insights into the underlying mechanisms of autoimmune diseases, lymphoid malignancies, and B-cell maturation processes.
The primary mechanism by which Tnfrsf17 Gene Knockout Cell Lines function is through the absence of the BAFF receptor. This receptor is crucial for B-cell survival and proliferation, and its knockout allows researchers to study altered cell signaling and phenotypic characteristics, such as reduced cell viability or changes in antibody production. Through the analysis of these cells, scientists can elucidate the pathways affected by BAFF signaling, ultimately contributing to a deeper understanding of immune system regulation.
In scientific research and clinical applications, Tnfrsf17 knockout models play a significant role in exploring potential therapeutic targets for diseases associated with aberrant B-cell activity. Their ability to simulate disease states in vitro accelerates the development of innovative treatments, making them invaluable for drug discovery and preclinical testing. This provides a critical advantage over traditional models, as they can yield more relevant insights into human pathophysiology.
What sets Tnfrsf17 Gene Knockout Cell Lines apart from alternative models is their precision and specificity. Conventional methods often involve complex backgrounds where multiple genes may influence outcomes, whereas our knockout lines offer a clean genetic slate focused solely on the effects of the Tnfrsf17 gene deletion, ensuring more reliable data interpretation. Moreover, these cell lines can be easily expanded and utilized across various experimental setups, enhancing their versatility for different research applications.
In conclusion, researchers and clinicians seeking to advance their understanding of B-cell functionality and related diseases will find Tnfrsf17 Gene Knockout Cell Lines to be an indispensable resource. Our expertise in developing high-quality biological products ensures reliability and consistency in these innovative cell lines, helping to drive forward the boundaries of scientific discovery and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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