Gene: TXNDC12
Official Full Name: thioredoxin domain containing 12provided by HGNC
Gene Summary: This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23137 | TXNDC12 Knockout cell line (HeLa) | Human | TXNDC12 | 1:3~1:6 | Negative | Online Inquiry |
KO23138 | TXNDC12 Knockout cell line (HCT 116) | Human | TXNDC12 | 1:2~1:4 | Negative | Online Inquiry |
KO23139 | TXNDC12 Knockout cell line (HEK293) | Human | TXNDC12 | 1:3~1:6 | Negative | Online Inquiry |
KO23140 | TXNDC12 Knockout cell line (A549) | Human | TXNDC12 | 1:3~1:4 | Negative | Online Inquiry |
TXNDC12 Gene Knockout Cell Lines are specifically engineered cellular models that have had the TXNDC12 gene disrupted, enabling researchers to investigate the gene's role in various biological processes and disease states. This gene encodes a member of the thioredoxin family, known for its involvement in the regulation of oxidative stress and protein folding. By knocking out TXNDC12, these cell lines allow for a detailed analysis of cellular responses, metabolic pathways, and the implications of TXNDC12 in diseases such as cancer and neurodegeneration.
The primary mechanism by which TXNDC12 Gene Knockout Cell Lines operate involves the elimination of the gene's functional protein product, leading to altered cellular homeostasis, changes in redox state, and impacts on protein quality control mechanisms. This enables researchers to explore the downstream effects, including altered signaling cascades and modifications in cellular behavior. The insights gained from using these knockout models are pivotal, as they provide essential data for elucidating how TXNDC12 contributes to pathophysiological processes and may unveil novel therapeutic targets.
Additionally, the utility of TXNDC12 Gene Knockout Cell Lines extends to clinical settings where understanding gene function can profoundly impact treatment strategies. These cell lines represent a critical tool for drug discovery, functional genomics, and the validation of targeted therapies. Compared to traditional cell lines, the specificity of gene knockout models offers unparalleled accuracy in dissecting molecular mechanisms, enabling researchers to make more informed decisions in their investigations.
Researchers, clinicians, and biopharmaceutical developers will find TXNDC12 Gene Knockout Cell Lines invaluable for advancing their studies on gene function and disease modeling, bolstering the potential for breakthroughs in therapeutic development. The product provides a powerful resource in the quest for understanding complex biological systems, thanks to the rigorous validation and quality assurance provided by our experienced team in genetic engineering and cell line development. Our commitment to advancing life sciences ensures that you have access to high-quality tools necessary for your research success.
Please note that all services are for research use only. Not intended for any clinical use.
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