Gene: TUG1
Official Full Name: taurine up-regulated 1provided by HGNC
Gene Summary: Predicted to enable cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within several processes, including mitochondrion organization; photoreceptor cell development; and spermatogenesis. Predicted to be located in mitochondrial membrane and nuclear membrane. Predicted to be active in nucleus. Biomarker of Huntington's disease. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20326 | TUG1 Knockout cell line (HeLa) | Human | TUG1 | 1:3~1:6 | Negative | Online Inquiry |
KO20327 | TUG1 Knockout cell line (HCT 116) | Human | TUG1 | 1:2~1:4 | Negative | Online Inquiry |
KO20328 | TUG1 Knockout cell line (HEK293) | Human | TUG1 | 1:3~1:6 | Negative | Online Inquiry |
KO20329 | TUG1 Knockout cell line (A549) | Human | TUG1 | 1:3~1:4 | Negative | Online Inquiry |
TUG1 Gene Knockout Cell Lines are specifically engineered cellular models that have had the TUG1 gene, a long non-coding RNA (lncRNA), inactivated or removed. This targeted gene knockout technique allows researchers to study the functional role of TUG1 within various biological contexts, including its implications in cancer biology, neurodevelopmental pathways, and other disease processes. By using CRISPR/Cas9 technology or specific RNA interference methods, these cell lines facilitate the precise elimination of the TUG1 gene, enabling researchers to observe resultant phenotypic changes and molecular interactions.
The key functions of TUG1 in cellular processes, particularly those involved in gene regulation and chromatin remodeling, make these knockout cell lines invaluable in studies aimed at unveiling underlying mechanisms of gene expression. Through the manipulation of the TUG1 gene, researchers can elucidate its contributions to cellular proliferation, differentiation, and apoptosis, providing critical insights relevant to disease pathology and potential therapeutic interventions.
The scientific importance of TUG1 Gene Knockout Cell Lines extends into various applications, both in fundamental research and translational settings. These cell lines serve as a critical resource for understanding the lncRNA landscape and its impact on genomic regulation. Furthermore, they hold promises for drug discovery and the development of targeted therapies, as elucidating the TUG1-related pathways may reveal new biomarkers or therapeutic targets.
Compared to alternative strategies such as overexpression models or non-targeted genetic modifications, TUG1 Gene Knockout Cell Lines offer a more precise approach to study gene function. The specificity of gene knockout eliminates the confounding effects associated with overexpression or partial inhibition, providing a clearer window into the role of TUG1 in various pathways.
Researchers, clinicians, and biotechnologists can greatly benefit from the availability of TUG1 Gene Knockout Cell Lines, as these models not only enhance the understanding of lncRNA biology but also support the development of innovative therapeutic strategies. By leveraging these sophisticated models, users can make significant strides in their research endeavors, accelerating scientific discovery and improving patient outcomes.
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Please note that all services are for research use only. Not intended for any clinical use.
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