Gene: TTL
Official Full Name: tubulin tyrosine ligaseprovided by HGNC
Gene Summary: TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22054 | TTL Knockout cell line (HeLa) | Human | TTL | 1:3~1:6 | Negative | Online Inquiry |
KO22055 | TTL Knockout cell line (HCT 116) | Human | TTL | 1:2~1:4 | Negative | Online Inquiry |
KO22056 | TTL Knockout cell line (HEK293) | Human | TTL | 1:3~1:6 | Negative | Online Inquiry |
KO22057 | TTL Knockout cell line (A549) | Human | TTL | 1:3~1:4 | Negative | Online Inquiry |
TTL Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of gene function and the biological significance of the TTL gene. These cell lines are created through advanced CRISPR-Cas9 gene-editing techniques, which precisely knockout the TTL gene, enabling researchers to investigate its role in various cellular processes, metabolic pathways, and disease mechanisms. The elimination of TTL allows for detailed assessment of phenotypic changes, thereby providing insight into the gene's role in regulating key biological functions.
Key mechanisms associated with these knockout cell lines include their ability to mimic pathological conditions by recapitulating the loss of the TTL gene’s expression. Researchers can utilize these models to assess changes in cellular behavior, such as differentiation, apoptosis, and response to pharmacological treatments. This functionality underscores the significance of TTL in areas such as neurology and cancer research, where understanding gene regulation is pivotal.
The scientific importance of TTL Gene Knockout Cell Lines extends into both basic and applied research, making them invaluable tools for drug discovery and development. Their application in clinical settings allows for more accurate modeling of diseases and the screening of potential therapeutic agents, thus bridging the gap between laboratory findings and clinical outcomes.
What sets our TTL Gene Knockout Cell Lines apart from alternatives is their reliability and reproducibility, ensuring that researchers achieve consistent results. Coupled with robust support from our team of experts in gene editing technologies, these cell lines are optimized for high-throughput applications, allowing researchers to save time and resources while achieving significant insights.
Investing in TTL Gene Knockout Cell Lines empowers scientists and clinicians by providing them with sophisticated tools essential for advancing their research and ultimately translating discoveries into practice. Our company, with years of dedicated expertise in biological innovations, offers a comprehensive range of solutions tailored to meet the growing demands in genetic research and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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