Gene: TSPAN5
Official Full Name: tetraspanin 5provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32295 | TSPAN5 Knockout cell line (HeLa) | Human | TSPAN5 | 1:3~1:6 | Negative | Online Inquiry |
KO32296 | TSPAN5 Knockout cell line (HCT 116) | Human | TSPAN5 | 1:2~1:4 | Negative | Online Inquiry |
KO32297 | TSPAN5 Knockout cell line (HEK293) | Human | TSPAN5 | 1:3~1:6 | Negative | Online Inquiry |
KO32298 | TSPAN5 Knockout cell line (A549) | Human | TSPAN5 | 1:3~1:4 | Negative | Online Inquiry |
TSPAN5 Gene Knockout Cell Lines are meticulously developed cellular models that provide researchers with unique tools for studying the functional role of the TSPAN5 gene, a member of the tetraspanin family known for its involvement in processes such as cell adhesion, signaling, and membrane organization. Through targeted gene editing technologies, these cell lines exhibit a complete knockout of TSPAN5 expression, allowing for a clearer dissection of its biological functions and associated pathways.
The primary mechanism underlying these cell lines lies in the CRISPR/Cas9 gene-editing technology used to introduce precise modifications at the genomic level. This approach not only ensures accuracy in knockout fidelity but also minimizes off-target effects, thus enhancing the reliability of experimental outcomes. In laboratory settings, the absence of TSPAN5 can significantly alter cellular behavior, providing a robust platform for investigating the implications in cancer biology, neurodevelopment, and immune response regulation, making these models invaluable in both research and potential clinical applications.
The scientific importance of TSPAN5 Gene Knockout Cell Lines is multifaceted. They facilitate the elucidation of TSPAN5’s role in disease pathology, contributing to the understanding of cellular mechanisms that could lead to new therapeutic targets. Compared with traditional methods that often rely on less precise genetic manipulations, these knockout cell lines offer heightened specificity and reproducibility, ensuring that findings are both valid and scalable.
For researchers and clinicians alike, the TSPAN5 Gene Knockout Cell Lines represent a powerful resource for advancing knowledge in cell biology and genetics. Their unique advantages, including precise gene editing, broad applicability across various research fields, and the capacity to yield translational data enhance their utility in laboratories aiming for impactful scientific breakthroughs.
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