Gene: TRPS1
Official Full Name: transcriptional repressor GATA binding 1provided by HGNC
Gene Summary: This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01706 | TRPS1 Knockout cell line (HeLa) | Human | TRPS1 | 1:3~1:6 | Negative | Online Inquiry |
KO01707 | TRPS1 Knockout cell line (HEK293) | Human | TRPS1 | 1:3~1:6 | Negative | Online Inquiry |
TRPS1 Gene Knockout Cell Lines are specialized cellular models engineered to lack the TRPS1 gene, which encodes a transcription factor critical for various cellular processes, particularly in skeletal development and epithelial function. These knockout cell lines serve as powerful tools for researchers to investigate the functional role of the TRPS1 gene, its downstream effectors, and its implications in pathological conditions such as growth disorders and cancer.
The key mechanism underlying the utility of TRPS1 Gene Knockout Cell Lines lies in their ability to elucidate gene function through loss of functionality. By comparing these knockout lines to their wild-type counterparts, researchers can assess changes in cellular behavior, differentiation, proliferation, and signaling pathways that may be influenced by TRPS1 expression. This level of detailed analysis is invaluable in characterizing the gene’s role in development and disease.
Scientifically, the use of TRPS1 Gene Knockout Cell Lines has significant importance in both basic research and clinical settings. They can reveal insights into the molecular mechanisms that underpin skeletal dysplasias, informing potential therapeutic avenues. Moreover, understanding TRPS1's behavior in the context of cancer biology may illuminate novel targets for intervention, providing pathways for developing innovative therapies.
Compared to alternative models, the specificity and precision of targeted gene knockout provide a clear advantage in studying unique gene functions without the confounding effects of partial gene expression. Other models may not fully recapitulate the complete loss of gene activity, thus potentially skewing results. TRPS1 Gene Knockout Cell Lines allow for a focused approach, enabling researchers to generate repeatable and reliable data.
Investing in TRPS1 Gene Knockout Cell Lines adds immense value to researchers and clinicians by streamlining the study of gene function and offering insights essential for disease understanding and therapeutic development. Our company prides itself on delivering high-quality biological products that enable cutting-edge research, and we are committed to supporting the scientific community with robust tools such as the TRPS1 Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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