Gene: TRPM7
Official Full Name: transient receptor potential cation channel subfamily M member 7provided by HGNC
Gene Summary: This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00208 | TRPM7 Knockout cell line (A549) | Human | TRPM7 | 1:3~1:4 | Negative | Online Inquiry |
KO00506 | TRPM7 Knockout cell line (HeLa) | Human | TRPM7 | 1:3~1:6 | Negative | Online Inquiry |
KO05238 | TRPM7 Knockout cell line (HCT 116) | Human | TRPM7 | 1:2~1:4 | Negative | Online Inquiry |
KO05239 | TRPM7 Knockout cell line (HEK293) | Human | TRPM7 | 1:3~1:6 | Negative | Online Inquiry |
TRPM7 Gene Knockout Cell Lines are engineered cellular models specifically designed to investigate the functional roles of the TRPM7 ion channel, a member of the transient receptor potential (TRP) family. By creating knockout versions of these cell lines, researchers can efficiently study the effects of TRPM7 depletion on cellular physiology without the confounding influence of the native gene product.
The primary function of the TRPM7 gene product is to facilitate the influx of divalent cations, such as magnesium and calcium, which are crucial for various cellular processes including signal transduction, cell proliferation, and apoptosis. These knockout cell lines provide a powerful tool for elucidating the specific pathways and mechanisms governed by TRPM7, thereby aiding in the understanding of its contributions to a variety of physiological and pathological conditions, including cardiac function, neuronal signaling, and cancer progression.
The scientific importance of these cell lines extends to both research and clinical settings, where they can serve as invaluable assets in drug discovery and therapeutic development. By utilizing TRPM7 knockout cell lines, researchers can explore the downstream effects of altered ion homeostasis, identify potential biomarkers for disease, and develop targeted therapies that could mitigate the impact of TRPM7 dysregulation.
One of the unique selling points of our TRPM7 Gene Knockout Cell Lines is their unparalleled specificity and reproducibility, which ensures that researchers obtain consistent results across experiments. Unlike traditional methods that may yield unintended genetic modifications, these knockout lines feature precise genomic edits that validate experimental conditions. Moreover, their ready availability significantly reduces developmental timelines for new research projects, facilitating faster advancements in the field.
In summary, TRPM7 Gene Knockout Cell Lines represent a critical innovation for scientists aiming to advance their understanding of cellular ion regulation and its biological implications. For researchers and clinicians alike, these cell lines offer a unique opportunity to unlock new frontiers in biomedical research. Our company, a leader in the production of high-quality cellular models, is committed to providing cutting-edge tools that enhance scientific discovery and contribute to novel therapeutic strategies.
Please note that all services are for research use only. Not intended for any clinical use.
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