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TRPM2 Knockout Cell Lines

Gene: TRPM2

Official Full Name: transient receptor potential cation channel subfamily M member 2provided by HGNC

Gene Summary: The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO09505 TRPM2 Knockout cell line (HeLa) Human TRPM2 1:3~1:6 Negative Online Inquiry
KO09506 TRPM2 Knockout cell line (HCT 116) Human TRPM2 1:2~1:4 Negative Online Inquiry
KO09507 TRPM2 Knockout cell line (A549) Human TRPM2 1:3~1:4 Negative Online Inquiry

Background

TRPM2 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to lack the transient receptor potential melastatin 2 (TRPM2) ion channel gene. These cell lines are invaluable tools for investigating the physiological and pathophysiological roles of TRPM2, which is notably implicated in various biological processes, including cellular responses to oxidative stress, inflammation, and metabolic disorders.

The primary function of TRPM2 is to mediate the influx of calcium ions into cells in response to metabolite signals and reactive oxygen species. By utilizing TRPM2 Gene Knockout Cell Lines, researchers can dissect the channel's specific contributions to cellular mechanisms, particularly in calcium signaling pathways and apoptosis. This enables a more profound understanding of TRPM2's role in various diseases, such as neurodegenerative disorders and cancer.

The scientific importance of these cell lines lies in their application in both fundamental research and clinical settings. They provide a unique opportunity to model diseases linked with TRPM2 dysregulation and offer insights into potential therapeutic interventions. With an increasingly recognized role in cellular stress responses, TRPM2 continues to be a focal point in drug discovery and development efforts.

When compared to alternative models, our TRPM2 Gene Knockout Cell Lines offer several advantages, including robust reproducibility, no off-target effects, and consistent performance across various experimental conditions. This reliability allows researchers and clinicians to draw insightful conclusions with confidence, ensuring that experimental outcomes are both meaningful and applicable.

For researchers and clinicians aiming to study TRPM2's diverse impacts, our TRPM2 Gene Knockout Cell Lines serve as an essential resource. Leveraging our commitment to high-quality biological products, our company stands at the forefront of genetic engineering, providing top-tier tools that empower scientific advancement and improve health outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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