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TRMU Knockout Cell Lines

Gene: TRMU

Official Full Name: tRNA mitochondrial 2-thiouridylaseprovided by HGNC

Gene Summary: This nuclear gene encodes a mitochondrial tRNA-modifying enzyme. The encoded protein catalyzes the 2-thiolation of uridine on the wobble positions of tRNA(Lys), tRNA(Glu), and tRNA(Gln), resulting in the formation of 5-taurinomethyl-2-thiouridine moieties. Mutations in this gene may cause transient infantile liver failure. Polymorphisms in this gene may also influence the severity of deafness caused by mitochondrial 12S ribosomal RNA mutations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13002 TRMU Knockout cell line (HeLa) Human TRMU 1:3~1:6 Negative Online Inquiry
KO13003 TRMU Knockout cell line (HCT 116) Human TRMU 1:2~1:4 Negative Online Inquiry
KO13004 TRMU Knockout cell line (HEK293) Human TRMU 1:3~1:6 Negative Online Inquiry
KO13005 TRMU Knockout cell line (A549) Human TRMU 1:3~1:4 Negative Online Inquiry

Background

TRMU Gene Knockout Cell Lines are specialized cellular models designed to facilitate the study of mitochondrial biology by targeting and inactivating the TRMU gene, which encodes a critical enzyme involved in mitochondrial tRNA modification. The TRMU gene is essential for the proper maturation of mitochondrial tRNA, which is crucial for the efficient translation of mitochondrial proteins necessary for energy production. By creating knockout cell lines, researchers can dissect the physiological roles of TRMU, explore its implications in mitochondrial dysfunction, and investigate pathways affected by impaired tRNA modifications.

The key function of TRMU Gene Knockout Cell Lines lies in their ability to elucidate the consequences of TRMU disruption, thereby allowing scientists to study mitochondrial diseases and their links to disorders such as neurodegeneration and cardiovascular diseases. The mechanistic insights derived from these models can pave the way for novel therapeutic strategies targeting mitochondrial function.

From a scientific perspective, these cell lines are invaluable in both basic and translational research. They offer a relevant platform for drug screening and testing the efficacy of therapeutic compounds aimed at restoring mitochondrial function. Moreover, the UTMRU knockout models can provide insights into cellular pathways that may be hijacked in cancer or metabolic diseases, enhancing our understanding of these complex conditions.

Compared to traditional methods involving non-specific gene editing, TRMU Gene Knockout Cell Lines offer precision and targeted inactivation, reducing off-target effects and ensuring that the observed phenotypes are directly attributable to TRMU disruption. This specificity enhances the reproducibility and reliability of experimental outcomes, making the data generated more robust.

In conclusion, the TRMU Gene Knockout Cell Lines stand out as essential tools for advancing mitochondrial research. Researchers and clinicians who wish to deepen their understanding of both fundamental and clinical aspects of mitochondrial biology will find these cell lines to be exceptionally valuable. Our company is dedicated to providing high-quality biological products, and with extensive expertise in cell line development and characterization, we ensure that our offerings meet the highest standards of scientific rigor and utility.

Please note that all services are for research use only. Not intended for any clinical use.

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