Gene: TRMT2B
Official Full Name: tRNA methyltransferase 2 homolog Bprovided by HGNC
Gene Summary: This gene encodes a homolog of the TRM2 gene in S. cerevisiae. The yeast gene encodes a tRNA methyltransferase that plays a role in tRNA maturation. The yeast protein also has endo-exonuclease activity and may be involved in DNA double strand break repair. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Nov 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13022 | TRMT2B Knockout cell line (HeLa) | Human | TRMT2B | 1:3~1:6 | Negative | Online Inquiry |
KO13023 | TRMT2B Knockout cell line (HCT 116) | Human | TRMT2B | 1:2~1:4 | Negative | Online Inquiry |
KO13024 | TRMT2B Knockout cell line (HEK293) | Human | TRMT2B | 1:3~1:6 | Negative | Online Inquiry |
KO13025 | TRMT2B Knockout cell line (A549) | Human | TRMT2B | 1:3~1:4 | Negative | Online Inquiry |
TRMT2B Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function of the TRMT2B gene, which is implicated in various biological processes, including RNA methylation. These knockout cell lines are created using CRISPR-Cas9 gene-editing technology, which allows precise alterations in the genomic DNA to disable the TRMT2B gene, effectively providing a model system to investigate its role in cellular mechanisms.
The key function of TRMT2B knockout cell lines lies in their ability to elucidate the consequences of the absence of this gene on cellular pathways, particularly those associated with ribosomal RNA modification and mitochondrial function. By analyzing these cells, researchers can gain insights into how TRMT2B may influence cellular metabolism and the regulation of gene expression, ultimately shedding light on its involvement in diseases such as cancer and metabolic disorders.
The scientific importance of these cell lines is multifaceted; they serve as vital tools for genetic research, drug discovery, and therapeutic development. Clinically, they can assist in understanding the molecular basis of diseases linked to TRMT2B dysregulation, paving the way for targeted therapies and personalized medicine approaches.
In comparison to traditional methods of studying gene function, such as overexpression studies or pharmacological interventions, TRMT2B knockout cell lines offer a more accurate representation of gene loss in vivo, providing a clearer understanding of the resultant phenotypic alterations. This precision makes them indispensable for researchers looking to explore gene function deeply and systematically.
For researchers and clinicians, the value of TRMT2B Gene Knockout Cell Lines is underscored by their role in advancing knowledge about gene function and disease mechanisms, facilitating innovative research that could translate into clinical applications.
Our company prides itself on its expertise in producing high-quality, genetically modified cell lines. We are dedicated to supporting the scientific community by providing tools that are not only reliable but also essential for groundbreaking discoveries in the field of molecular biology and genetics.
Please note that all services are for research use only. Not intended for any clinical use.
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