Gene: TRMT10B
Official Full Name: tRNA methyltransferase 10Bprovided by HGNC
Gene Summary: Enables tRNA (guanosine(9)-N1)-methyltransferase activity. Involved in protein insertion into mitochondrial inner membrane. Located in cytosol. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13018 | TRMT10B Knockout cell line (HeLa) | Human | TRMT10B | 1:3~1:6 | Negative | Online Inquiry |
KO13019 | TRMT10B Knockout cell line (HCT 116) | Human | TRMT10B | 1:2~1:4 | Negative | Online Inquiry |
KO13020 | TRMT10B Knockout cell line (HEK293) | Human | TRMT10B | 1:3~1:6 | Negative | Online Inquiry |
KO13021 | TRMT10B Knockout cell line (A549) | Human | TRMT10B | 1:3~1:4 | Negative | Online Inquiry |
TRMT10B Gene Knockout Cell Lines are specialized cellular models engineered to eliminate the TRMT10B gene expression, which encodes for an essential enzyme involved in tRNA methylation. This process is critical for maintaining proper protein synthesis and cellular function. By knocking out TRMT10B, researchers can study its effects on tRNA modification, gene expression regulation, and overall cellular metabolism.
The primary function of these knockout cell lines lies in their ability to facilitate investigations into the molecular mechanisms surrounding tRNA methylation. Specifically, without the TRMT10B gene, cells exhibit altered tRNA methylation patterns, allowing scientists to observe downstream effects on translation fidelity and efficiency. This provides a unique vantage point for elucidating the functional relationships between tRNA modifications and cellular physiology, paving the way for insights into various biological processes including cellular stress responses and disease states.
From a scientific standpoint, TRMT10B Gene Knockout Cell Lines are invaluable in both research and clinical contexts. They can be utilized to explore the role of tRNA modifications in cancer biology, neurodegenerative diseases, and developmental processes, making them a powerful tool for drug discovery and therapeutic interventions.
One of the primary advantages of using TRMT10B Gene Knockout Cell Lines is their specificity and reproducibility, which are often lacking in alternative models. Additionally, these cell lines allow for the examination of gene function in an in vitro system that closely mimics physiological conditions, leading to more accurate and translatable findings.
For researchers and clinicians focused on gene regulation and tRNA biology, these knockout cell lines represent a highly valuable resource. By leveraging the insights gained from these models, users can contribute to advancements in understanding the fundamental mechanisms that underlie numerous health conditions.
Our company prides itself on its commitment to advancing biological research through the provision of high-quality genetic models. With expertise in cell line development and genetic engineering, we offer a diverse portfolio of products that empower scientists to uncover critical biological insights and drive innovation in their respective fields.
Please note that all services are for research use only. Not intended for any clinical use.
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