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TRMT10A Knockout Cell Lines

Gene: TRMT10A

Official Full Name: tRNA methyltransferase 10Aprovided by HGNC

Gene Summary: This gene encodes a protein that belongs to the tRNA (Guanine-1)-methyltransferase family. A similar gene in yeast modifies several different tRNA species. Mutations in this gene are associated with microcephaly, short stature, and impaired glucose metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22161 TRMT10A Knockout cell line (HeLa) Human TRMT10A 1:3~1:6 Negative Online Inquiry
KO22162 TRMT10A Knockout cell line (HCT 116) Human TRMT10A 1:2~1:4 Negative Online Inquiry
KO22163 TRMT10A Knockout cell line (HEK293) Human TRMT10A 1:3~1:6 Negative Online Inquiry
KO22164 TRMT10A Knockout cell line (A549) Human TRMT10A 1:3~1:4 Negative Online Inquiry

Background

TRMT10A Gene Knockout Cell Lines are specially engineered cellular models that enable researchers to study the biological functions associated with the TRMT10A gene, which is implicated in various biological processes, including mitochondrial function and RNA modification. By knocking out the TRMT10A gene, these cell lines serve as vital tools for elucidating the gene's role in cellular metabolism and disease mechanisms, particularly in the context of certain cancers and mitochondrial disorders.

The primary function of these cell lines lies in their ability to mimic the absence of the TRMT10A protein, allowing for comprehensive investigation into the cellular pathways affected by its loss. Mechanistically, TRMT10A is involved in the modification of mitochondrial tRNA, which is essential for proper mitochondrial protein synthesis. Understanding the impact of TRMT10A depletion helps elucidate the connection between mitochondrial dysfunction and cellular stress responses, thereby providing insights into potential therapeutic targets.

The scientific importance of TRMT10A Gene Knockout Cell Lines cannot be overstated. They are invaluable in both fundamental research and clinical studies, offering researchers a robust platform to explore the genetic and biochemical pathways regulated by TRMT10A. These cell lines can be used in high-throughput screening, drug discovery, and the development of gene therapies, presenting a wide range of applications in health and disease studies.

Compared to traditional wild-type cell lines, the TRMT10A knockout models provide a unique advantage by creating a controlled environment to study gene function more precisely. This specificity facilitates the identification of novel biomarkers and therapeutic targets, making it easier for researchers to design strategies against diseases associated with TRMT10A dysfunction.

Overall, the value of TRMT10A Gene Knockout Cell Lines extends beyond just a research tool; they play a crucial role in advancing understanding of genetic contributions to health and disease. By equipping researchers, clinicians, and biotech firms with this innovative resource, our company reaffirms its commitment to providing advanced biological products that support breakthroughs in modern medicine and life science research.

Please note that all services are for research use only. Not intended for any clinical use.

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