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TRIP12 Knockout Cell Lines

Gene: TRIP12

Official Full Name: thyroid hormone receptor interactor 12provided by HGNC

Gene Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33331 TRIP12 Knockout cell line (HeLa) Human TRIP12 1:3~1:6 Negative Online Inquiry
KO33332 TRIP12 Knockout cell line (HCT 116) Human TRIP12 1:2~1:4 Negative Online Inquiry
KO33333 TRIP12 Knockout cell line (HEK293) Human TRIP12 1:3~1:6 Negative Online Inquiry
KO33334 TRIP12 Knockout cell line (A549) Human TRIP12 1:3~1:4 Negative Online Inquiry

Background

TRIP12 Gene Knockout Cell Lines are a groundbreaking biological tool designed to facilitate the study of the TRIP12 gene, which encodes an E3 ubiquitin ligase involved in diverse cellular processes, including DNA repair, cell cycle regulation, and the modulation of the immune response. These knockout cell lines are engineered using advanced CRISPR-Cas9 technology to create a specific deletion of the TRIP12 gene, allowing researchers to investigate the gene's functional role in various biological contexts.

The primary function of these knockout cell lines is to provide a controlled environment for examining the effects of TRIP12 deficiency on critical cellular pathways. By comparing the knockout cell lines with wild-type controls, researchers can elucidate the gene’s involvement in cellular signaling, proliferation, apoptosis, and other vital biological processes. The mechanisms underlying the phenotypic changes observed can lead to deeper insights into TRIP12-related diseases, offering a potential avenue for therapeutic development.

In scientific research and clinical settings, TRIP12 Gene Knockout Cell Lines are invaluable for elucidating gene function, validating drug targets, and exploring the mechanisms of disease progression. Their capacity to model diseases, such as cancer and autoimmune disorders, ensures relevance in both fundamental research and applied therapeutic strategies.

What sets these cell lines apart from alternatives is their high specificity and efficiency in creating a precise gene knockout. Traditional knockout mouse models involve lengthy procedures, but these cell lines provide a more streamlined and quicker approach to studying the effects of gene disruption. Furthermore, they are readily adaptable to high-throughput screening methods, enhancing their appeal for pharmacological studies.

For researchers and clinicians invested in the intricate interplay of genetics and disease, TRIP12 Gene Knockout Cell Lines represent a powerful asset that facilitates innovative exploration and discovery. As a leader in biological product development, our company is committed to providing high-quality, reliable tools that empower scientific advancement, fostering collaborations that nurtures research excellence.

Please note that all services are for research use only. Not intended for any clinical use.

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