Gene: TRIM27
Official Full Name: tripartite motif containing 27provided by HGNC
Gene Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO03276 | TRIM27 Knockout cell line (HeLa) | Human | TRIM27 | 1:3~1:6 | Negative | Online Inquiry |
KO03277 | TRIM27 Knockout cell line (HCT 116) | Human | TRIM27 | 1:2~1:4 | Negative | Online Inquiry |
KO03278 | TRIM27 Knockout cell line (HEK293) | Human | TRIM27 | 1:3~1:6 | Negative | Online Inquiry |
KO03279 | TRIM27 Knockout cell line (A549) | Human | TRIM27 | 1:3~1:4 | Negative | Online Inquiry |
TRIM27 Gene Knockout Cell Lines are specialized cell lines that have been genetically modified to disrupt the TRIM27 gene, a member of the tripartite motif (TRIM) family, which has been implicated in various cellular processes, including protein ubiquitination and transcriptional regulation. By utilizing CRISPR-Cas9 technology, these knockout cell lines enable researchers to investigate the functional roles of TRIM27 and its associated pathways in disease models.
The primary function of TRIM27 in cellular biology relates to its involvement in the regulation of protein degradation and signaling pathways. By knocking out this gene, researchers can observe the downstream effects on various biological processes, particularly in cancer biology, immune response, and metabolic regulation. The absence of TRIM27 can reveal insights into its role as a potential tumor suppressor or oncogene, allowing for a better understanding of its contribution to pathophysiological conditions.
In research and clinical settings, TRIM27 Gene Knockout Cell Lines serve as essential tools for dissecting the molecular mechanisms underlying diseases such as cancer, autoimmune disorders, and metabolic syndromes. They can facilitate drug discovery by enabling the identification of novel therapeutic targets and the evaluation of treatment efficacy in a controlled environment, thus bridging the gap between basic research and clinical applications.
Compared to other gene knockout models, our TRIM27 cell lines are optimized for stability and reproducibility. They come with validated genetic modifications and extensive supporting documentation, ensuring high confidence in experimental outcomes. Additionally, the user-friendly protocols we provide simplify the process of working with these knockout lines, saving researchers valuable time and minimizing potential setbacks.
These products are invaluable to researchers and clinicians aiming to explore the complexities of gene function and therapeutic interventions. By investing in TRIM27 Gene Knockout Cell Lines, users position themselves at the forefront of cutting-edge research, equipped with the tools necessary to advance their investigations into significant biological questions.
Our company is dedicated to empowering scientific discovery through high-quality biological products and innovative solutions. With a commitment to excellence in research and development, we provide resources that enhance experimental accuracy and reliability, thus fostering groundbreaking advancements in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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