Gene: TRAPPC12
Official Full Name: trafficking protein particle complex subunit 12provided by HGNC
Gene Summary: Involved in several processes, including endoplasmic reticulum to Golgi vesicle-mediated transport; positive regulation of protein localization to kinetochore; and regulation of kinetochore assembly. Located in several cellular components, including endoplasmic reticulum-Golgi intermediate compartment; kinetochore; and perinuclear region of cytoplasm. Part of TRAPP complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO23018 | TRAPPC12 Knockout cell line (HeLa) | Human | TRAPPC12 | 1:3~1:6 | Negative | Online Inquiry |
KO23019 | TRAPPC12 Knockout cell line (HCT 116) | Human | TRAPPC12 | 1:2~1:4 | Negative | Online Inquiry |
KO23020 | TRAPPC12 Knockout cell line (HEK293) | Human | TRAPPC12 | 1:3~1:6 | Negative | Online Inquiry |
KO23021 | TRAPPC12 Knockout cell line (A549) | Human | TRAPPC12 | 1:3~1:4 | Negative | Online Inquiry |
TRAPPC12 Gene Knockout Cell Lines represent a critical tool for advancing our understanding of cellular signaling pathways and their implications in various biological processes. TRAPPC12, or Trafficking Protein Particle Complex Subunit 12, is an essential component of the TRAPP (Transport Protein Particle) complex, which plays a significant role in the regulation of protein transport and membrane trafficking within cells. By creating knockout cell lines, researchers can precisely investigate the effects of TRAPPC12 deletion on cellular function, thereby elucidating its role in key processes such as autophagy, secretion, and signal transduction.
The primary mechanism underlying the functionality of these cell lines involves the disruption of TRAPPC12 protein expression, which can lead to altered vesicle formation and trafficking dynamics. This modification allows researchers to explore the resulting phenotypic changes and correlate them with specific biological outcomes, providing invaluable insights into pathophysiological conditions linked to dysfunction in protein transport mechanisms, such as neurodegenerative diseases or certain cancers.
The scientific importance of TRAPPC12 Gene Knockout Cell Lines extends into both research and clinical settings. Their ability to model diseases at the cellular level enables scientists to identify potential therapeutic targets and develop novel treatments. In a laboratory setting, these cell lines are pivotal for high-throughput screening, enabling researchers to assess compound efficacy or toxicity rapidly.
One of the standout advantages of our TRAPPC12 Gene Knockout Cell Lines over alternatives is their precision gene editing, which ensures that the knockout effect is specific and reproducible. Moreover, these cell lines are validated for consistency across experiments, giving researchers confidence in their results. Our product is also compatible with a range of downstream applications, including genome-wide screening and CRISPR-Cas9 methodologies, making it versatile for various experimental designs.
By choosing TRAPPC12 Gene Knockout Cell Lines, researchers and clinicians gain access to a cutting-edge tool that enhances experimental reliability and opens new avenues for discovery. Our company is committed to delivering high-quality biological products backed by extensive expertise in molecular biology, ensuring that every customer receives the support and knowledge necessary to maximize their research potential.
Please note that all services are for research use only. Not intended for any clinical use.
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