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TRAP1 Knockout Cell Lines

Gene: TRAP1

Official Full Name: TNF receptor associated protein 1provided by HGNC

Gene Summary: This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32253 TRAP1 Knockout cell line (HeLa) Human TRAP1 1:3~1:6 Negative Online Inquiry
KO32254 TRAP1 Knockout cell line (HCT 116) Human TRAP1 1:2~1:4 Negative Online Inquiry
KO32255 TRAP1 Knockout cell line (HEK293) Human TRAP1 1:3~1:6 Negative Online Inquiry
KO32256 TRAP1 Knockout cell line (A549) Human TRAP1 1:3~1:4 Negative Online Inquiry

Background

TRAP1 Gene Knockout Cell Lines are engineered cellular models where the TRAP1 (tumor necrosis factor receptor-associated protein 1) gene has been specifically inactivated, allowing researchers to investigate the role of this critical gene in various biological processes. The gene is known to be involved in mitochondrial function, cellular metabolism, and stress responses, making these knockout cell lines invaluable for studying disease mechanisms, particularly in cancer, neurodegenerative disorders, and metabolic diseases.

The primary function of TRAP1 involves modulating mitochondrial chaperoning and maintaining cellular homeostasis. By utilizing TRAP1 Gene Knockout Cell Lines, researchers can observe the consequences of TRAP1 loss on cellular bioenergetics, apoptosis, and reactive oxygen species (ROS) production. This is essential for elucidating how TRAP1 contributes to malignancy, as its dysregulation is often linked to poor patient outcomes in cancers. The knockout model facilitates a more straightforward assessment of gene function and its downstream signaling pathways, offering insights that are critical for developing targeted therapies.

The scientific importance of TRAP1 Gene Knockout Cell Lines lies in their broad applicability across research and clinical settings. These cell lines serve as robust platforms for drug screening, functional genomics, and pathway analysis, enabling the discovery of novel therapeutic targets and biomarkers. Furthermore, these models can help validate findings from in vitro studies and contribute to more translational research efforts.

Compared to alternative models, TRAP1 Gene Knockout Cell Lines offer specificity and reliability, providing a clear understanding of TRAP1 function without the complications that may arise from partial inhibition or off-target effects. Additionally, the characterization of these cell lines prior to use ensures high reproducibility of results, which is crucial for driving impactful research.

For researchers, clinicians, and pharmaceutical developers, the TRAP1 Gene Knockout Cell Lines represent a unique opportunity to deepen their understanding of mitochondrial biology and its implications for human health. Given the increasing emphasis on precision medicine, integrating such models into research pipelines can drastically accelerate the identification and validation of novel therapies.

At [Your Company], our expertise in cellular engineering and commitment to advancing scientific discovery ensure that we provide high-quality biological products tailored to meet the rigorous demands of modern research, empowering researchers in their quest to unravel the complexities of human disease.

Please note that all services are for research use only. Not intended for any clinical use.

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