Gene: TPP2
Official Full Name: tripeptidyl peptidase 2provided by HGNC
Gene Summary: This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO04980 | TPP2 Knockout cell line (HeLa) | Human | TPP2 | 1:3~1:6 | Negative | Online Inquiry |
KO04981 | TPP2 Knockout cell line (HCT 116) | Human | TPP2 | 1:2~1:4 | Negative | Online Inquiry |
KO04982 | TPP2 Knockout cell line (HEK293) | Human | TPP2 | 1:3~1:6 | Negative | Online Inquiry |
KO04983 | TPP2 Knockout cell line (A549) | Human | TPP2 | 1:3~1:4 | Negative | Online Inquiry |
TPP2 Gene Knockout Cell Lines are a powerful tool specifically designed to facilitate the investigation of cellular functions regulated by the TPP2 gene. These genetically engineered cell lines have been developed through precise gene editing techniques, like CRISPR/Cas9, resulting in complete ablation of the TPP2 gene expression. By eliminating this gene, researchers can examine the resulting phenotypic changes, providing insights into the role of TPP2 in various biological processes, including protein degradation, cellular stress response, and signaling pathways.
The primary function of the TPP2 Gene Knockout Cell Lines lies in their ability to mimic disease states and offer a platform for studying the underlying mechanisms of cellular dysregulation. The absence of TPP2 enhances the understanding of its interactions with other proteins and pathways, enabling researchers to dissect complex signaling networks. Moreover, these cell lines serve as a useful model for drug discovery, allowing for the identification of potential therapeutic targets and the assessment of drug efficacy.
Scientifically, TPP2 knockout models are pivotal in translational research and contribute valuable data on metabolic diseases, cancer biology, and neurodegenerative disorders, thus bridging the gap between basic research and clinical applications. Compared to wild-type cell lines or alternatives that may not provide as clear insights into TPP2 function, these knockout cell lines offer specificity and clarity in studying TPP2-related pathways.
The advantages of using TPP2 Gene Knockout Cell Lines extend beyond their scientific capabilities. These cell lines are easy to incorporate into existing research frameworks and compatible with high-throughput screening processes. Furthermore, the reproducibility and reliability of data generated from these models make them indispensable for researchers aiming to publish high-impact findings.
In a rapidly evolving field, our company stands out for its commitment to advancing biological research through innovative solutions, specializing in the development of high-quality gene knockout models. By choosing TPP2 Gene Knockout Cell Lines, researchers and clinicians can leverage cutting-edge technology to deepen their understanding of TPP2's role in health and disease.
Please note that all services are for research use only. Not intended for any clinical use.
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