Gene: Tpm1
Official Full Name: tropomyosin 1provided by RGD
Gene Summary: This gene is a member of the tropomyosin family and encodes a protein that heterodimerizes with a beta subunit, binding actin in both muscle and nonmuscle cells. In both smooth and striated muscle cells, it plays a role in calcium dependent-regulation of muscle contraction. In nonmuscle cells, it stabilizes cytoskeleton actin filaments. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34954 | TPM1 Knockout cell line (HeLa) | Human | TPM1 | 1:3~1:6 | Negative | Online Inquiry |
KO34955 | TPM1 Knockout cell line (HCT 116) | Human | TPM1 | 1:2~1:4 | Negative | Online Inquiry |
KO34956 | TPM1 Knockout cell line (HEK293) | Human | TPM1 | 1:3~1:6 | Negative | Online Inquiry |
KO34957 | TPM1 Knockout cell line (A549) | Human | TPM1 | 1:3~1:4 | Negative | Online Inquiry |
Tpm1 Gene Knockout Cell Lines represent a sophisticated tool designed to facilitate the study of cellular mechanisms and disease pathways associated with the tropomyosin-1 gene (Tpm1). These cell lines are genetically engineered to have a complete knockout of the Tpm1 gene, allowing researchers to investigate the functional consequences of its absence in various cellular contexts. The loss of Tpm1, which encodes a key actin-regulatory protein, affects cytoskeletal dynamics, influencing cellular processes such as migration, division, and signal transduction.
The primary function of these Tpm1 Gene Knockout Cell Lines lies in their ability to serve as a model for studying the role of tropomyosin in health and disease, particularly in cancer metastasis, cardiovascular disorders, and muscle-related pathologies. By analyzing the biological responses of these knockout cells, researchers can elucidate the molecular pathways affected by Tpm1 absence and how these contribute to disease phenotypes.
In research settings, these knockout cell lines enhance the precision of functional studies and drug discovery initiatives. Their availability equips laboratories with a consistent and reliable system to examine the effects of Tpm1 modulation in vitro, which is particularly valuable for high-throughput screening of potential therapeutic agents.
Compared to alternative models, Tpm1 Gene Knockout Cell Lines offer specific advantages, including improved phenotype consistency, straightforward genetic characterization, and the elimination of confounding variables associated with endogenous Tpm1 expression. This specificity enables more accurate assessments of potential treatments targeting pathways influenced by Tpm1.
These cell lines enhance the toolkit for researchers and clinicians by providing insights that can drive innovations in therapeutic strategies and deepen the understanding of Tpm1-related conditions. Leveraging our extensive expertise in genetic engineering, our company is proud to deliver Tpm1 Gene Knockout Cell Lines as part of our commitment to advancing biomedical research and clinical applications.
Please note that all services are for research use only. Not intended for any clinical use.
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