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TOX3 Knockout Cell Lines

Gene: TOX3

Official Full Name: TOX high mobility group box family member 3provided by HGNC

Gene Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO06444 TOX3 Knockout cell line (HEK293) Human TOX3 1:3~1:6 Negative Online Inquiry

Background

TOX3 Gene Knockout Cell Lines are specially engineered cell models that have been genetically modified to disable the expression of the TOX3 gene, which has been implicated in various biological processes including neuronal differentiation and disease mechanisms. This product serves as a critical tool for researchers focused on dissecting the roles of TOX3 in both normal physiology and pathological conditions, such as neurodegenerative diseases and certain cancers.

The primary function of TOX3 Gene Knockout Cell Lines is to provide a controlled environment in which the absence of TOX3 can be studied. By employing CRISPR-Cas9 technology, scientists can effectively create a targeted knockout of the TOX3 gene, enabling investigations into downstream signaling pathways, gene expression changes, and cellular behaviors influenced by this gene. Researchers can also assess how loss of TOX3 contributes to various cellular phenotypes, offering insights into its function at molecular and cellular levels.

The scientific importance of these cell lines is underscored by their utility in both basic and applied research contexts. In academic settings, they allow for exploration of the gene’s role in cellular processes, contributing to the understanding of gene function in differentiation and disease. In clinical research, these cell lines can serve as models for drug discovery, particularly in identifying therapeutic targets involved in diseases associated with TOX3 dysregulation.

When compared to alternative models, TOX3 Gene Knockout Cell Lines stand out due to their specificity and precision in targeting the gene of interest. While traditional knockdown methods, such as siRNA, can provide interim insights, knockout models offer a more definitive approach by permanently disabling the gene, thus allowing for thorough and reproducible analysis of TOX3’s functional role.

These cell lines are invaluable assets for researchers and clinicians alike, as they not only facilitate a deeper understanding of gene function but also pave the way for potential therapeutic interventions. Equip your laboratory with TOX3 Gene Knockout Cell Lines for high-quality research that can contribute meaningfully to our understanding of complex biological systems. Our company has a proven track record of providing cutting-edge biological tools, ensuring you receive reliable and robust products tailored to your research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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