Gene: TNRC6C
Official Full Name: trinucleotide repeat containing adaptor 6Cprovided by HGNC
Gene Summary: Predicted to enable RNA binding activity. Involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13121 | TNRC6C Knockout cell line (HCT 116) | Human | TNRC6C | 1:2~1:4 | Negative | Online Inquiry |
KO13122 | TNRC6C Knockout cell line (HEK293) | Human | TNRC6C | 1:3~1:6 | Negative | Online Inquiry |
KO13123 | TNRC6C Knockout cell line (A549) | Human | TNRC6C | 1:3~1:4 | Negative | Online Inquiry |
TNRC6C gene knockout cell lines are advanced biological tools designed specifically for the study of gene function, regulation, and interactions within cellular contexts. The TNRC6C gene, encoding a protein integral to the miRNA-mediated gene silencing pathway, plays a significant role in the post-transcriptional regulation of gene expression. By creating knockout cell lines—where the TNRC6C gene is inactivated—researchers can explore the implications of its absence on cellular behavior, gene expression profiles, and signal transduction pathways.
The primary function of TNRC6C knockout cell lines lies in their ability to uncouple gene regulation mechanisms associated with miRNA activity. These cell lines facilitate the investigation of the role TNRC6C plays in stabilizing miRNA-mRNA complexes, providing insights into how gene silencing is altered when this protein is absent. This is critical in understanding various biological processes, including development, differentiation, and responses to stress, as well as in the context of diseases like cancer, where miRNA dysregulation is commonly observed.
In both research and clinical settings, the applications of TNRC6C knockout cell lines are extensive. They can be utilized in drug development, providing a platform to assess the therapeutic potential of compounds that target miRNA pathways. Additionally, they can help elucidate mechanisms of resistance to therapies in cancer models, making them invaluable for translational research.
Our TNRC6C knockout cell lines stand out due to their rigorous characterization, reproducibility, and ease of use in various experimental setups, allowing for straightforward integration into existing research methodologies. Unlike traditional knockdown approaches, these knockout models provide a more definitive understanding of the pathways affected by the absence of TNRC6C, making them a superior choice for researchers seeking clarity and precision in their studies.
With a commitment to innovation and excellence, our company offers high-quality gene knockout cell lines that empower researchers and clinicians to advance their understanding of fundamental biological processes and develop novel therapeutic strategies. We pride ourselves on our expertise in cell line development and our dedication to supporting the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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