TNFSF10 Knockout Cell Lines

Gene: TNFSF10

Official Full Name: TNF superfamily member 10provided by HGNC

Gene Summary: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO09941	TNFSF10 Knockout cell line (HeLa)	Human	TNFSF10	1:3~1:6	Negative	Online Inquiry

Background

TNFSF10 Gene Knockout Cell Lines are specifically engineered cellular models designed to lack the Tumor Necrosis Factor Superfamily Member 10 (TNFSF10), also known as TRAIL (TNF-related apoptosis-inducing ligand). This gene plays a critical role in modulating apoptosis (programmed cell death) and immune responses, making these knockout cell lines invaluable tools for studying cancer biology, immunology, and therapeutic mechanisms.

These cell lines function by providing a controlled environment where researchers can evaluate the effects of TRAIL absence on cellular mechanisms and signaling pathways. The knockout of TNFSF10 allows for the exploration of alternative apoptosis pathways and their contributions to tumor survival and immune evasion. This is particularly important in cancer research where understanding the interactions between tumor cells and the immune system can lead to breakthroughs in treatment strategies.

The scientific importance of TNFSF10 Gene Knockout Cell Lines lies in their wide-ranging applications. In research settings, they are used to screen novel anticancer compounds, identify biomarkers for cancer prognosis, and develop immunotherapies targeting resistant cancers. In clinical applications, insights gained from studies using these cell lines can influence the development of more effective treatment regimens.

What sets our TNFSF10 Gene Knockout Cell Lines apart from alternatives is their rigorous validation and high reproducibility, ensuring that researchers can trust their results. They come with detailed characterization data and protocols to facilitate ease of use, reducing the time from concept to experimental outcome.

For researchers and clinicians aiming to unravel the complexities of cancer and explore innovative therapies, our TNFSF10 Gene Knockout Cell Lines offer an essential resource. Backed by our company’s expertise in genetic engineering and high-quality cell culture products, we are committed to providing cutting-edge solutions that advance scientific discovery and improve clinical outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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