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TNFAIP2 Knockout Cell Lines

Gene: TNFAIP2

Official Full Name: TNF alpha induced protein 2provided by HGNC

Gene Summary: This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34970 TNFAIP2 Knockout cell line (HeLa) Human TNFAIP2 1:3~1:6 Negative Online Inquiry
KO34971 TNFAIP2 Knockout cell line (HCT 116) Human TNFAIP2 1:2~1:4 Negative Online Inquiry
KO34972 TNFAIP2 Knockout cell line (A549) Human TNFAIP2 1:3~1:4 Negative Online Inquiry

Background

TNFAIP2 Gene Knockout Cell Lines are specifically engineered cellular models used to study the roles and implications of the Tumor Necrosis Factor Alpha-Induced Protein 2 (TNFAIP2) gene in various biological processes and diseases. These cells have undergone targeted gene modifications to completely eliminate the expression of TNFAIP2, allowing researchers to investigate the functional consequences of this gene's absence.

The key mechanisms by which these knockout cell lines operate involve the disruption of TNFAIP2’s regulatory pathways, impacting processes such as inflammation, apoptosis, and immune response. In research contexts, TNFAIP2 plays a crucial role in cellular signaling, particularly concerning the TNF-alpha pathway, which is significant for understanding conditions such as autoimmune diseases, cancer, and tissue repair.

The scientific importance of TNFAIP2 Gene Knockout Cell Lines cannot be overstated, as they provide invaluable insights into gene function, disease mechanisms, and potential therapeutic targets. Researchers utilize these models to elucidate the downstream effects of TNFAIP2 deficiency, highlighting its implications in disease pathology and the biological significance of cytokine interactions.

Compared to traditional wild-type cell lines, these knockout models offer a distinct advantage by allowing for the precise investigation of TNFAIP2's specific contributions to cellular behavior without interference from functional alleles. Furthermore, using TNFAIP2-deficient cells can enhance the robustness of experimental results, enabling the development of more targeted and effective therapeutic strategies.

For scientists, clinicians, or pharmaceutical researchers, the TNFAIP2 Gene Knockout Cell Lines present a reliable and straightforward tool for advancing their understanding of complex biological systems. With the capability to help bridge the gap between basic research and clinical application, these products enable significant progress towards novel treatment modalities.

Our company specializes in providing high-quality biological research tools, backed by extensive expertise in genetic engineering and cellular biology. We are committed to supporting the scientific community with innovative solutions tailored to meet the demands of modern research.

Please note that all services are for research use only. Not intended for any clinical use.

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