TMPRSS3 Knockout Cell Lines

Gene: TMPRSS3

Official Full Name: transmembrane serine protease 3provided by HGNC

Gene Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

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Products Background

Products

Catalog Number	Product Name	Species	Gene	Passage ratio	Mycoplasma testing	Price
KO13158	TMPRSS3 Knockout cell line (HeLa)	Human	TMPRSS3	1:3~1:6	Negative	Online Inquiry

Background

TMPRSS3 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to investigate the biological functions and pathways involving the Transmembrane Protease, Serine 3 (TMPRSS3) gene. These cell lines have been engineered through CRISPR-Cas9 technology to create targeted deletions within the TMPRSS3 gene, enabling researchers to analyze the resulting phenotypic and molecular changes.

The primary function of TMPRSS3 is associated with the processing of certain proteins and modulating various signaling pathways, including those linked to human hearing and certain cancers. By studying these knockout cell lines, researchers can elucidate the role of TMPRSS3 in cellular processes, including its impact on the proteolytic maturation of viral glycoproteins and its implications in auditory function, thereby opening avenues for targeted therapeutic interventions.

Scientifically, these cell lines hold great importance in both research and clinical settings, offering an invaluable tool for understanding the etiology of TMPRSS3-related disorders, such as auditory neuropathy and potential malignancies. The knockout model allows for precise dissection of gene function and facilitates screening for novel compounds that might reverse or ameliorate the pathogenic effects associated with TMPRSS3 aberrations.

The TMPRSS3 Gene Knockout Cell Lines stand out due to their specificity, reproducibility, and ease of use compared to traditional methods, such as RNA interference or transgenic models. Providing a stable genetic background, these cell lines allow for prolonged observation of cellular behavior and response to external stimuli, making them exceptional resources for pharmaceutical development and gene therapy research.

Valuable to researchers and clinicians alike, our TMPRSS3 Gene Knockout Cell Lines enable rigorous investigation into gene function and disease mechanisms, accelerating the discovery of new therapeutic strategies. Supported by our company’s extensive expertise in genetic engineering and bioproduction, we are committed to advancing your research with high-quality biological models that drive scientific innovation and clinical breakthroughs.

Please note that all services are for research use only. Not intended for any clinical use.

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