Gene: TMOD1
Official Full Name: tropomodulin 1provided by HGNC
Gene Summary: This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO34981 | TMOD1 Knockout cell line (HeLa) | Human | TMOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO34982 | TMOD1 Knockout cell line (HCT 116) | Human | TMOD1 | 1:2~1:4 | Negative | Online Inquiry |
KO34983 | TMOD1 Knockout cell line (HEK293) | Human | TMOD1 | 1:3~1:6 | Negative | Online Inquiry |
KO34984 | TMOD1 Knockout cell line (A549) | Human | TMOD1 | 1:3~1:4 | Negative | Online Inquiry |
TMOD1 Gene Knockout Cell Lines are a valuable tool for investigating the functional role of the Tropomodulin 1 (TMOD1) gene, which is crucial for actin filament capping and stabilization in muscle cells and other tissues. These cell lines have been engineered to possess a complete knockout of the TMOD1 gene, allowing researchers to study the resulting phenotypic changes and elucidate the gene's involvement in various biological processes, including muscle development, cardiomyopathy, and cytoskeletal organization.
The primary mechanism by which TMOD1 operates involves its ability to bind to the pointed ends of actin filaments, thereby preventing further elongation and disassembly of the cytoskeletal structure. By using TMOD1 Gene Knockout Cell Lines, scientists can investigate how the absence of this key regulator affects actin dynamics, cellular morphology, and signaling pathways, providing insights into the molecular underpinnings of diseases associated with cytoskeletal dysfunction.
Scientifically, these cell lines hold importance in both research and clinical settings as they enable a deeper understanding of muscle pathology and related disorders. Moreover, they are instrumental in preclinical studies aimed at developing potential therapeutic strategies for conditions linked to aberrations in actin regulation.
Compared to conventional methods of studying gene function, such as siRNA-mediated knockdown, TMOD1 Gene Knockout Cell Lines offer a more complete and stable model for examining gene function across various cell types. They provide robust experimental systems that can be used for high-throughput screening and drug discovery, making them a superior choice for researchers seeking reliable data on gene function.
For researchers and clinicians working in the fields of molecular biology, genetics, and pathology, our TMOD1 Gene Knockout Cell Lines represent a strategic investment in advancing scientific knowledge and therapeutic development. Our company specializes in providing high-quality, genetically modified cell lines tailored for specific research needs, backed by years of expertise in the field of cell biology and genetic engineering.
Please note that all services are for research use only. Not intended for any clinical use.
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