Gene: TMEM214
Official Full Name: transmembrane protein 214provided by HGNC
Gene Summary: Predicted to be involved in apoptotic process. Located in several cellular components, including Golgi apparatus; cytoplasmic microtubule; and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00969 | TMEM214 gRNA5-gRNA6 KO plasmid | TMEM214 | $850 | |||
KO00294 | TMEM214 Knockout cell line (ARPE-19) | Human | TMEM214 | 1:3~1:5 | Negative | Online Inquiry |
KO02447 | TMEM214 Knockout cell line (HeLa) | Human | TMEM214 | 1:3~1:6 | Negative | Online Inquiry |
KO02448 | TMEM214 Knockout cell line (HCT 116) | Human | TMEM214 | 1:2~1:4 | Negative | Online Inquiry |
KO02449 | TMEM214 Knockout cell line (HEK293) | Human | TMEM214 | 1:3~1:6 | Negative | Online Inquiry |
KO02450 | TMEM214 Knockout cell line (A549) | Human | TMEM214 | 1:3~1:4 | Negative | Online Inquiry |
TMEM214 Gene Knockout Cell Lines are engineered cellular models that possess a targeted disruption of the TMEM214 gene, which encodes a protein involved in various cellular processes, including ion transport and cellular signaling pathways. These knockout cell lines are generated through advanced genetic engineering techniques, typically utilizing CRISPR-Cas9 technology, to ensure precise edits with high efficiency. By eliminating the functionality of TMEM214, these cell lines serve as valuable tools for elucidating the gene's role in physiological and pathological processes.
The primary function of these cell lines is to allow researchers to study the specific outcomes of TMEM214 depletion in a controlled environment. This includes assessing alterations in cellular behavior, such as proliferation, apoptosis, and response to stressors. The knockout cell lines provide a robust platform for examining the broader implications of TMEM214 in diseases, particularly in the context of cancer and metabolic disorders, where aberrant ion transport and signaling pathways play critical roles.
Scientifically, the TMEM214 knockout cell lines are instrumental in advancing our understanding of gene function and interaction networks. In clinical research, they facilitate the exploration of novel therapeutic targets and biomarker discovery, enabling the development of innovative treatments. They also offer the prospect of high-throughput screening for pharmacological agents that could restore or compensate for the loss of TMEM214 activity.
What sets these cell lines apart from traditional models is their specificity and reliability. Unlike general gene knockdown methods, such as RNA interference, CRISPR-mediated knockout provides a complete loss-of-function scenario, resulting in more definitive conclusions. Moreover, their consistent performance across experiments enhances reproducibility, a crucial aspect of scientific research.
For researchers and clinicians alike, the TMEM214 Gene Knockout Cell Lines represent a strategic addition to the toolbox of modern biological research, offering unmatched capabilities for gene function studies. Our company prides itself on utilizing cutting-edge genetic engineering techniques to create high-quality research tools, ensuring that our customers have access to the best resources available for their investigative needs.
Please note that all services are for research use only. Not intended for any clinical use.
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