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TMEM143 Knockout Cell Lines

Gene: TMEM143

Official Full Name: transmembrane protein 143provided by HGNC

Gene Summary: Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13251 TMEM143 Knockout cell line (HeLa) Human TMEM143 1:3~1:6 Negative Online Inquiry
KO13252 TMEM143 Knockout cell line (HCT 116) Human TMEM143 1:2~1:4 Negative Online Inquiry
KO13253 TMEM143 Knockout cell line (HEK293) Human TMEM143 1:3~1:6 Negative Online Inquiry
KO13254 TMEM143 Knockout cell line (A549) Human TMEM143 1:3~1:4 Negative Online Inquiry

Background

TMEM143 Gene Knockout Cell Lines are engineered cellular models designed to study the functional implications of the TMEM143 gene, which is implicated in a variety of cellular processes including ion transport and cellular signaling pathways. These cell lines are generated using CRISPR-Cas9 technology, allowing for the precise and efficient disruption of the TMEM143 gene. As a result, researchers can investigate the gene's role in pathological conditions such as cardiovascular diseases and metabolic disorders.

The key function of the TMEM143 gene knockout cell lines lies in their ability to serve as powerful tools for functional genomics studies. By comparing these knockout cells with wild-type counterparts, researchers can elucidate the biological pathways and mechanisms that are disrupted in the absence of TMEM143. This is particularly valuable in the context of drug discovery and development, as it allows scientists to identify potential therapeutic targets and biomarkers associated with specific diseases.

The scientific importance of these cell lines extends to both research and clinical applications. For instance, they enable researchers to model disease states more accurately, facilitating a better understanding of TMEM143’s role in cellular physiology and pathology. Furthermore, these models can drive innovation in gene therapy approaches and personalized medicine by revealing how genetic alterations contribute to disease processes.

Compared to alternative genetic manipulation methods, such as traditional RNA interference or older gene targeting techniques, TMEM143 gene knockout cell lines provide a more efficient and reliable means of generating stable, reproducible models that precisely mimic the loss of function of the target gene. This allows for increased confidence in experimental outcomes and data reliability, which is crucial for advancing scientific knowledge.

For researchers and clinicians alike, the TMEM143 Gene Knockout Cell Lines offer invaluable insight into the intricate workings of gene-function relationships. This product not only accelerates the pace of research but also enhances the potential for translational applications aimed at developing targeted therapies, making it an indispensable resource in modern biological research.

At [Your Company Name], we pride ourselves on our commitment to providing high-quality, reliable biological products backed by rigorous scientific expertise. Our TMEM143 Gene Knockout Cell Lines embody this commitment, equipping researchers with the tools necessary to pioneer future breakthroughs in genomics and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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