Gene: TMEM127
Official Full Name: transmembrane protein 127provided by HGNC
Gene Summary: This gene encodes a transmembrane protein with four predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2022]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00273 | TMEM127 Knockout cell line (HeLa) | Human | TMEM127 | 1:3~1:6 | Negative | Online Inquiry |
KO13259 | TMEM127 Knockout cell line (HCT 116) | Human | TMEM127 | 1:2~1:4 | Negative | Online Inquiry |
KO13260 | TMEM127 Knockout cell line (HEK293) | Human | TMEM127 | 1:3~1:6 | Negative | Online Inquiry |
KO13261 | TMEM127 Knockout cell line (A549) | Human | TMEM127 | 1:3~1:4 | Negative | Online Inquiry |
TMEM127 Gene Knockout Cell Lines are specialized cellular models that have had the TMEM127 gene genetically disrupted, enabling the study of the gene's role in various biological processes and diseases. The TMEM127 gene encodes for a protein that is implicated in the regulation of mTOR signaling pathways, which are crucial for cellular growth, metabolism, and proliferation. By utilizing these knockout cell lines, researchers can investigate the downstream effects of mTOR dysregulation, offering insights into diseases such as cancer, metabolic disorders, and neurodegenerative conditions.
The primary function of these cell lines is to serve as a tool for elucidating the biological pathways influenced by TMEM127. Researchers employ these models to perform functional assays, gene expression analyses, and pathway elucidation. The absence of the TMEM127 gene allows for direct comparison of metabolic and proliferative behaviors against wild-type controls, highlighting the gene’s specific contributions.
The scientific importance of TMEM127 Gene Knockout Cell Lines extends beyond basic research; they have significant applications in drug discovery and personalized medicine. By understanding the mechanisms of TMEM127 regulation, researchers can identify potential therapeutic targets for malignancies and other diseases that exhibit mTOR pathway aberrations.
Compared to alternative systems, such as transient knockdown models, these knockout cell lines offer greater stability and reproducibility in experiments. The permanent alteration of the gene allows researchers to conduct long-term studies and obtain consistent data across multiple experiments, which is essential for validating findings.
For researchers and clinicians, investing in TMEM127 Gene Knockout Cell Lines translates into gaining access to a powerful tool for advanced investigation into cellular mechanisms and therapeutic developments. The knowledge obtained from studies utilizing these knockout models could pave the way for the discovery of novel treatment strategies.
Our company specializes in high-quality genetic models, providing researchers with the resources and expertise needed to advance their studies. With a strong commitment to scientific excellence, our products like the TMEM127 Gene Knockout Cell Lines are designed to accelerate discovery and innovation in the field of biology.
Please note that all services are for research use only. Not intended for any clinical use.
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