Gene: TLK1
Official Full Name: tousled like kinase 1provided by HGNC
Gene Summary: The protein encoded by this gene is a serine/threonine kinase that may be involved in the regulation of chromatin assembly. The encoded protein is only active when it is phosphorylated, and this phosphorylation is cell cycle-dependent, with the maximal activity of this protein coming during S phase. The catalytic activity of this protein is diminished by DNA damage and by blockage of DNA replication. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO32595 | TLK1 Knockout cell line (HeLa) | Human | TLK1 | 1:3~1:6 | Negative | Online Inquiry |
KO32596 | TLK1 Knockout cell line (HCT 116) | Human | TLK1 | 1:2~1:4 | Negative | Online Inquiry |
KO32597 | TLK1 Knockout cell line (HEK293) | Human | TLK1 | 1:3~1:6 | Negative | Online Inquiry |
KO32598 | TLK1 Knockout cell line (A549) | Human | TLK1 | 1:3~1:4 | Negative | Online Inquiry |
TLK1 Gene Knockout Cell Lines are genetically engineered cellular models designed to study the function of the Thymine Kinase 1 (TLK1) gene through precise gene editing techniques. The knockout of TLK1 allows researchers to investigate its role in cellular processes, such as DNA repair, cell cycle regulation, and apoptosis, thereby facilitating a deeper understanding of its implications in various diseases, including cancer and neurodegenerative disorders.
Functionally, these cell lines employ CRISPR/Cas9 technology for the targeted disruption of the TLK1 gene. This mechanism permits the generation of isogenic cell lines that lack TLK1 expression, enabling comparative studies between wild-type and knockout scenarios. Such a controlled environment is crucial for uncovering the biochemical pathways influenced by TLK1 activity and understanding its involvement in cellular responses to genotoxic stress or therapeutic interventions.
The scientific importance of TLK1 Gene Knockout Cell Lines extends to research and clinical applications, providing valuable insights into the molecular underpinnings of genomic stability and tumorigenesis. They serve as essential tools in drug discovery, allowing pharmacologists and biochemists to test new compounds' efficacy in a TLK1-deficient context, potentially leading to innovative therapeutic strategies targeting TLK1-related pathways.
What sets our TLK1 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility, which are often compromised in conventional gene-silencing methods. Furthermore, our suite of knockout cell lines is validated and characterized for multiple applications, ensuring that researchers can rely on quality results that contribute to authentic scientific advancement.
Ultimately, investing in TLK1 Gene Knockout Cell Lines empowers researchers and clinicians to unlock the biological mysteries behind the TLK1 gene, fostering innovations that could significantly impact treatment protocols. Our company stands at the forefront of genetic research product development, offering expertly crafted solutions designed to meet the evolving needs of the scientific community, backed by years of experience and dedication to advancing life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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