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THOP1 Knockout Cell Lines

Gene: THOP1

Official Full Name: thimet oligopeptidase 1provided by HGNC

Gene Summary: The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35014 THOP1 Knockout cell line (HeLa) Human THOP1 1:3~1:6 Negative Online Inquiry
KO35015 THOP1 Knockout cell line (HCT 116) Human THOP1 1:2~1:4 Negative Online Inquiry
KO35016 THOP1 Knockout cell line (HEK293) Human THOP1 1:3~1:6 Negative Online Inquiry
KO35017 THOP1 Knockout cell line (A549) Human THOP1 1:3~1:4 Negative Online Inquiry

Background

THOP1 Gene Knockout Cell Lines are genetically engineered cell lines that have had the THOP1 gene selectively inactivated, enabling researchers to investigate the functional roles and biological significance of this gene in various pathways and diseases. This precise knockout allows for the detailed study of THOP1's involvement in physiological processes, such as protein metabolism and cell signaling, by providing a model system in which the impact and compensatory mechanisms of the absence of this gene can be closely observed.

The mechanisms of action of these cell lines revolve around their ability to mimic pathological states by eliminating THOP1, thus creating an environment that simulates certain disease conditions. This is crucial for discerning the gene's contributions to protein interactions and the downstream effects in metabolic pathways. Researchers can utilize these cell lines to perform knockdown studies, drug testing, and mechanistic insights into diseases where THOP1 may play a role, such as cancers and neurodegenerative disorders.

The scientific importance of THOP1 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical settings. They serve as invaluable tools for drug discovery, validation of therapeutic targets, and understanding gene function and regulation. Moreover, they provide insights into the broader implications of gene knockout strategies in vivo, leading to advancements in precision medicine.

One of the primary advantages of these cell lines is their specificity and reliability compared to other gene manipulation techniques, such as CRISPR/Cas9, which can introduce off-target effects. The well-characterized nature of these knockout lines ensures consistency across experiments, enhancing reproducibility—an essential criterion in scientific research.

For researchers and clinicians alike, THOP1 Gene Knockout Cell Lines present a compelling opportunity to unlock new avenues in gene function exploration and therapeutic development. The ability to study the precise consequences of THOP1 inactivation without the confounding variables found in less controlled systems provides a unique edge in both laboratory studies and translational research.

Our company possesses extensive expertise in genetic engineering and cell line development, ensuring that each of our biological products, including the THOP1 Gene Knockout Cell Lines, meets the highest standards of quality and performance. We are committed to supporting scientific innovation through precision tools that drive forward research endeavors.

Please note that all services are for research use only. Not intended for any clinical use.

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