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THEM4 Knockout Cell Lines

Gene: THEM4

Official Full Name: thioesterase superfamily member 4provided by HGNC

Gene Summary: Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10133 THEM4 Knockout cell line (HeLa) Human THEM4 1:3~1:6 Negative Online Inquiry
KO10134 THEM4 Knockout cell line (HCT 116) Human THEM4 1:2~1:4 Negative Online Inquiry
KO10135 THEM4 Knockout cell line (HEK293) Human THEM4 1:3~1:6 Negative Online Inquiry
KO10136 THEM4 Knockout cell line (A549) Human THEM4 1:3~1:4 Negative Online Inquiry

Background

THEM4 Gene Knockout Cell Lines are advanced cellular models that have been genetically engineered to possess a complete deficiency of the THEM4 gene, enabling researchers to investigate the functional roles of this specific gene in various biological processes. By employing CRISPR-Cas9 gene editing technology, these cell lines provide a reliable framework for dissecting the pathophysiological implications of THEM4 in cellular metabolism, cell signaling, and disease mechanisms.

The primary function of THEM4 is linked to its role in metabolic regulation and cellular stress responses. In the context of cellular studies, the knockout of THEM4 facilitates the exploration of its involvement in processes such as apoptosis, cellular differentiation, and mitochondrial function. Researchers can utilize these cell lines to dissect the downstream effects of THEM4 deletion, contributing to a deeper understanding of cellular pathways and potential therapeutic targets for diseases where THEM4 has been implicated, including metabolic disorders and cancer.

The scientific importance of THEM4 Gene Knockout Cell Lines extends to both research and clinical settings. In drug development, these models can be instrumental for screening compounds that modulate the functions associated with THEM4. Furthermore, understanding the ramifications of THEM4 deficiency can lead to novel insights into the molecular underpinnings of disease and inform targeted therapeutic strategies.

What sets our THEM4 Gene Knockout Cell Lines apart is the rigorous validation through genomic sequencing and phenotypic characterization, ensuring high specificity and reproducibility that exceeds conventional models. Researchers will find that these cell lines significantly accelerate their projects by eliminating ambiguities associated with genetic background variability.

In summary, our THEM4 Gene Knockout Cell Lines stand as an invaluable asset for the scientific community, enabling researchers and clinicians alike to unravel the complexities of gene function and disease pathways. With a commitment to excellence in biotechnological advancements, our company leverages years of expertise in genetic engineering to deliver high-quality products that empower scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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