Gene: THBS4
Official Full Name: thrombospondin 4provided by HGNC
Gene Summary: The protein encoded by this gene belongs to the thrombospondin protein family. Thrombospondin family members are adhesive glycoproteins that mediate cell-to-cell and cell-to-matrix interactions. This protein forms a pentamer and can bind to heparin and calcium. It is involved in local signaling in the developing and adult nervous system, and it contributes to spinal sensitization and neuropathic pain states. This gene is activated during the stromal response to invasive breast cancer. It may also play a role in inflammatory responses in Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13424 | THBS4 Knockout cell line (HCT 116) | Human | THBS4 | 1:2~1:4 | Negative | Online Inquiry |
THBS4 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the biological functions and molecular pathways associated with the thrombospondin-4 (THBS4) gene. By employing CRISPR-Cas9 technology or similar gene-editing techniques, these cell lines have been meticulously crafted to eliminate the expression of the THBS4 gene. This knockout model facilitates in-depth investigation of the role THBS4 plays in various physiological and pathological processes, including cell adhesion, migration, and the regulation of angiogenesis.
The core function of the THBS4 Gene Knockout Cell Lines lies in their ability to serve as a reliable platform for assessing the consequences of THBS4 deficiency. Researchers can explore alterations in extracellular matrix composition, cellular response to growth factors, and the impact on various signaling pathways. Such insights are critical for understanding the gene's involvement in diseases such as cancer, cardiovascular disorders, and neurodegeneration, making these cell lines invaluable tools in both basic and applied research.
In clinical settings, the ability to induce specific gene knockout allows for targeted therapeutic strategies, potentially leading to the development of innovative treatments. Unlike conventional models, these knockout cell lines provide a more precise understanding of gene function through the lens of loss-of-function experiments, thereby enhancing the reliability of experimental outcomes.
One of the significant advantages of THBS4 Gene Knockout Cell Lines is their customization and adaptability for a range of experimental needs. These lines provide reproducibility in results that may not be achievable with primary cells or other conventional cell lines, thereby increasing the robustness of experimental designs. Additionally, they are compatible with various assays, including drug screening and gene expression analysis.
For researchers and clinicians focused on translational medicine or cellular biology, THBS4 Gene Knockout Cell Lines stand out as an essential asset. They encapsulate the potential to unravel complex biological interactions while paving the way for discovering novel therapeutic interventions.
As a leader in biotechnological innovations, our company leverages extensive expertise in genetic engineering and cellular biology to provide high-quality biological products like the THBS4 Gene Knockout Cell Lines, ensuring researchers have the tools necessary to advance their scientific inquiries effectively.
Please note that all services are for research use only. Not intended for any clinical use.
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