Gene: TGIF2
Official Full Name: TGFB induced factor homeobox 2provided by HGNC
Gene Summary: The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20827 | TGIF2 Knockout cell line (HeLa) | Human | TGIF2 | 1:3~1:6 | Negative | Online Inquiry |
KO20828 | TGIF2 Knockout cell line (HCT 116) | Human | TGIF2 | 1:2~1:4 | Negative | Online Inquiry |
KO20829 | TGIF2 Knockout cell line (HEK293) | Human | TGIF2 | 1:3~1:6 | Negative | Online Inquiry |
KO20830 | TGIF2 Knockout cell line (A549) | Human | TGIF2 | 1:3~1:4 | Negative | Online Inquiry |
TGIF2 Gene Knockout Cell Lines are specialized cellular models created for the in-depth study of the TGIF2 gene's function and its role in various biological processes. These cell lines have been engineered to eliminate the expression of the TGIF2 gene through advanced gene-editing techniques, allowing researchers to investigate the gene's involvement in embryonic development, cell signaling pathways, and disease mechanisms such as cancer and congenital disorders.
The primary mechanism of these knockout cell lines involves the disruption of TGIF2’s coding sequence, leading to a complete loss of function. This allows for the assessment of the phenotypic consequences of TGIF2 absence in controlled laboratory settings. Researchers utilize these models to elucidate the gene's role in transcriptional regulation, and its interactions with other proteins, thus gaining insights into the molecular underpinnings of critical biological phenomena.
The scientific importance of TGIF2 Gene Knockout Cell Lines extends into both research and clinical contexts. In basic research, these models enable investigators to dissect genetic pathways and discover novel therapeutic targets. In clinical settings, understanding TGIF2's function may contribute to the identification of biomarkers for disease susceptibility or progression, potentially leading to more effective treatment strategies.
What sets our TGIF2 Gene Knockout Cell Lines apart is their high efficiency, reliability, and the comprehensive characterization that accompanies each cell line. Compared to other gene-editing products, our cell lines undergo rigorous validation, ensuring that researchers receive tools that are accurately representative of TGIF2 knockout conditions.
This product is invaluable to researchers and clinicians alike, offering a pathway to uncover new biological insights and paving the way for innovations in therapeutic developments. By incorporating our TGIF2 Gene Knockout Cell Lines into your research portfolio, you can enhance the robustness and translational relevance of your findings.
Our company prides itself on its commitment to quality and innovation in biological products, backed by a team of experienced professionals dedicated to supporting scientific advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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