Gene: TGFB1I1
Official Full Name: transforming growth factor beta 1 induced transcript 1provided by HGNC
Gene Summary: This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35024 | TGFB1I1 Knockout cell line (HeLa) | Human | TGFB1I1 | 1:3~1:6 | Negative | Online Inquiry |
KO35025 | TGFB1I1 Knockout cell line (HCT 116) | Human | TGFB1I1 | 1:2~1:4 | Negative | Online Inquiry |
KO35026 | TGFB1I1 Knockout cell line (A549) | Human | TGFB1I1 | 1:3~1:4 | Negative | Online Inquiry |
TGFB1I1 Gene Knockout Cell Lines represent a cutting-edge innovation in cellular biology, designed to facilitate in-depth research into the biological roles of the TGFB1I1 gene. This gene encodes a protein known as TGF-beta signaling inhibitor, which plays a crucial role in modulating the cellular response to TGF-beta signaling, a pathway integral to various cellular processes including proliferation, differentiation, and apoptosis. The availability of these knockout cell lines enables researchers to study the full impact of TGFB1I1 depletion, providing insights into its role in development, cancer progression, and fibrotic diseases.
These cell lines operate through the precise removal of the TGFB1I1 gene, allowing scientists to investigate alterations in TGF-beta pathway activity and associated downstream effects. By employing CRISPR/Cas9 or similar gene-editing technologies, these cell lines serve as a powerful tool for dissecting complex signaling networks, examining phenotypic changes, and understanding gene interactions in physiological and pathological contexts.
In terms of scientific importance, TGFB1I1 knockout cell lines have significant applications across various research domains, including cancer biology, regenerative medicine, and immunology. Their ability to unveil the nuances of TGF-beta signaling pathways bears implications for targeted therapies and the development of novel pharmacological interventions.
Compared to standard cell lines that express the TGFB1I1 gene, these knockout models provide a unique advantage by eliminating confounding variables, thus giving researchers clearer insights into gene function and downstream effects. This specificity can enhance the validity of experimental results, ultimately leading to more robust conclusions and discoveries.
Researchers and clinicians alike can find immense value in TGFB1I1 gene knockout cell lines—not only as a resource for understanding fundamental biological processes but also as a springboard for translational research aimed at devising new therapeutic strategies for related diseases.
With a proven track record in providing high-quality biological products, our company is committed to supporting the scientific community by offering reliable and innovative tools that enhance research capabilities and streamline experimental design. This dedication to quality and service makes us a trusted partner in advancing scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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