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TGDS Knockout Cell Lines

Gene: TGDS

Official Full Name: TDP-glucose 4,6-dehydrataseprovided by HGNC

Gene Summary: The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29264 TGDS Knockout cell line (HeLa) Human TGDS 1:3~1:6 Negative Online Inquiry
KO29265 TGDS Knockout cell line (HCT 116) Human TGDS 1:2~1:4 Negative Online Inquiry
KO29266 TGDS Knockout cell line (HEK293) Human TGDS 1:3~1:6 Negative Online Inquiry
KO29267 TGDS Knockout cell line (A549) Human TGDS 1:3~1:4 Negative Online Inquiry

Background

TGDS Gene Knockout Cell Lines are precisely engineered cellular models designed to facilitate in-depth functional studies of the TGDS gene. These cell lines have been genetically modified to disable the TGDS gene, providing researchers with powerful tools to analyze gene function, elucidate metabolic pathways, and assess the implications of TGDS in various physiological and pathological contexts.

The key function of TGDS Gene Knockout Cell Lines lies in their ability to enable targeted investigations into the biological role of the TGDS gene. By knocking out this specific gene, scientists can observe the resultant phenotypic changes in cellular behavior, including alterations in lipid metabolism and signaling pathways, which are essential to comprehending diseases such as cancer and metabolic disorders. The knockout mechanism utilizes CRISPR/Cas9 technology, allowing for precise genetic modifications and reproducible results that are vital for validating experimental hypotheses.

Scientifically, these cell lines play an instrumental role in advancing research in molecular biology, genetics, and drug development. In clinical settings, they are invaluable for drug discovery projects that target TGDS-related pathways, helping to identify potential therapeutic candidates and mechanisms of action. Applications extend from academic research to biopharmaceutical development, exemplifying their versatility and relevance.

Compared to traditional knockout models, which often involve cumbersome and time-consuming methodologies, TGDS Gene Knockout Cell Lines offer rapid generation times and improved specificity, minimizing off-target effects. This efficiency allows for faster experimental workflows and more robust data generation, providing a competitive edge to researchers in need of reliable and reproducible experimental models.

With the increasing need for advanced gene-editing tools in biomedical research, the TGDS Gene Knockout Cell Lines stand out as essential resources for those aiming to push the boundaries of knowledge in genomics and associated fields. Our company brings years of expertise in genetic engineering and cell line development to the forefront, ensuring that our products not only meet but exceed the demands of today's innovative research environments.

Please note that all services are for research use only. Not intended for any clinical use.

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