Gene: TFE3
Official Full Name: transcription factor binding to IGHM enhancer 3provided by HGNC
Gene Summary: This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00523 | TFE3 Knockout cell line (HeLa) | Human | TFE3 | 1:3~1:6 | Negative | Online Inquiry |
KO07205 | TFE3 Knockout cell line (HCT 116) | Human | TFE3 | 1:2~1:4 | Negative | Online Inquiry |
KO07206 | TFE3 Knockout cell line (HEK293) | Human | TFE3 | 1:3~1:6 | Negative | Online Inquiry |
KO07207 | TFE3 Knockout cell line (A549) | Human | TFE3 | 1:3~1:4 | Negative | Online Inquiry |
TFE3 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to study the function and implications of the TFE3 transcription factor in cellular and molecular biology. Utilizing CRISPR/Cas9 technology, these cell lines have had the TFE3 gene disrupted, allowing researchers to investigate the resulting phenotypic changes and molecular pathways involved. Through the knockout of this gene, which is associated with various oncogenic processes and cellular stress responses, scientists can elucidate the role of TFE3 in tumorigenesis, metabolism, and signal transduction.
The key mechanism underpinning the utility of TFE3 Gene Knockout Cell Lines lies in their ability to provide a controlled environment for experimentation, facilitating the study of TFE3-dependent processes. Researchers can analyze differences in gene expression, protein interactions, and cellular behaviors compared to wild-type cells. This understanding is crucial in clinical research where TFE3 has emerged as a significant player in renal cell carcinoma and other malignancies, offering potential biomarkers and therapeutic targets.
What sets our TFE3 Gene Knockout Cell Lines apart from alternative models is the precision and reliability afforded by our cloning protocols, which ensure high knockout efficiency and specificity. Additionally, our cell lines are rigorously validated for functional attributes, enabling robust experimental outcomes that are reproducible across various assays.
The strategic importance of this product is underscored by its application in both basic and applied research settings, particularly within oncology, developmental biology, and systems biology. With increasing demand for high-fidelity model systems, the TFE3 Gene Knockout Cell Lines represent an invaluable tool for scientists delving into gene function, signaling pathways, and disease mechanisms.
As a company dedicated to advancing biological research, we bring extensive expertise in gene editing technologies and a commitment to providing superior products that empower researchers in their quest for knowledge and innovation. Our high-quality offerings ensure that users have the best resources available to drive impactful discoveries in their fields.
Please note that all services are for research use only. Not intended for any clinical use.
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