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TESK2 Knockout Cell Lines

Gene: TESK2

Official Full Name: testis associated actin remodelling kinase 2provided by HGNC

Gene Summary: This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain that is structurally similar to the kinase domains of testis-specific protein kinase-1 and the LIM motif-containing protein kinases (LIMKs). Its overall structure is most related to the former, indicating that it belongs to the TESK subgroup of the LIMK/TESK family of protein kinases. This gene is predominantly expressed in testis and prostate. The developmental expression pattern of the rat gene in testis suggests an important role for this gene in meitoic stages and/or early stages of spermiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31895 TESK2 Knockout cell line (HeLa) Human TESK2 1:3~1:6 Negative Online Inquiry
KO31896 TESK2 Knockout cell line (HCT 116) Human TESK2 1:2~1:4 Negative Online Inquiry
KO31897 TESK2 Knockout cell line (HEK293) Human TESK2 1:3~1:6 Negative Online Inquiry

Background

TESK2 Gene Knockout Cell Lines are meticulously engineered cellular models designed to facilitate the study of the TESK2 (Testis-specific Serine Kinase 2) gene's role in various biological processes. These cell lines have been developed using advanced CRISPR-Cas9 technology to excise the TESK2 gene, resulting in knockout cells that provide invaluable insights into the gene's function and its implications in cellular biology and pathophysiology.

The primary function of the TESK2 Gene Knockout Cell Lines is to enable researchers to delineate the mechanisms through which the TESK2 protein influences cellular signaling pathways, particularly those involved in cell proliferation, migration, and survival. By comparing the behavior of knockout cells to their wild-type counterparts, scientists can elucidate the role of TESK2 in conditions such as cancer, reproductive health, and developmental biology.

Scientific importance is underscored by the emerging evidence linking the TESK2 gene with critical cellular pathways, making these knockout cell lines particularly useful in both research and clinical applications. They serve as a foundational tool for drug discovery, allowing for the assessment of potential therapeutic interventions targeting TESK2-associated pathways. Additionally, these cell lines can significantly advance the understanding of infertility or tumorigenesis linked to TESK2 dysfunction.

One noteworthy advantage of our TESK2 Gene Knockout Cell Lines lies in their specificity; while alternatives often involve partial knockdowns or overexpression systems, our fully characterized knockout models provide a clear picture of gene function without the confounding effects associated with incomplete genetic edits. Furthermore, our cells are rigorously validated for consistent performance across experiments, ensuring reliability in experimental outcomes.

Researchers and clinicians will find significant value in these cell lines due to their potential to aid in the identification of biomarkers and therapeutic targets related to TESK2 activity. By providing a robust platform for functional studies, our product enhances the ability to develop precision medicine approaches tailored to specific pathogenic conditions.

Our company specializes in delivering leading-edge biological research tools, backed by a team of experts committed to supporting innovative discoveries in cellular and molecular biology. With a focus on high-quality, rigorously tested products, we empower the scientific community to advance their research with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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