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TCIM Knockout Cell Lines

Gene: TCIM

Official Full Name: transcriptional and immune response regulatorprovided by HGNC

Gene Summary: This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20301 TCIM Knockout cell line (HeLa) Human TCIM 1:3~1:6 Negative Online Inquiry
KO20302 TCIM Knockout cell line (A549) Human TCIM 1:3~1:4 Negative Online Inquiry

Background

TCIM Gene Knockout Cell Lines are sophisticated biological tools designed for the precise study of gene function and molecular pathways. These cell lines have undergone targeted gene editing using CRISPR-Cas9 technology to effectively disable specific genes of interest, thereby allowing researchers to investigate the resulting phenotypic changes. By systematically knocking out genes, scientists can delineate the roles of these genes in various biological processes, evaluate cellular responses, and explore the underlying mechanisms of diseases.

The key functions of TCIM Gene Knockout Cell Lines are rooted in their ability to create controlled environments that closely mimic human physiological conditions. Researchers utilize these lines to analyze gene interactions, cellular signaling, and the impact on metabolic pathways. With a catalog of knockouts representing various genes implicated in health and disease, these cell lines serve as invaluable models for drug discovery, toxicity testing, and the development of therapeutic strategies.

The scientific importance of TCIM Gene Knockout Cell Lines is underscored by their applications in both research and clinical settings. They are particularly beneficial for studying genetic contributions to complex diseases, such as cancer, neurodegeneration, and metabolic disorders. In clinical laboratories, these models facilitate personalized medicine approaches by allowing for the assessment of genetic susceptibilities and responses to different treatment regimens.

Compared to conventional gene knockout methods, TCIM Gene Knockout Cell Lines offer several advantages, including higher specificity and efficiency, reduced off-target effects, and rapid generation of stable cell lines. These features empower researchers to achieve more reliable and reproducible results, ultimately accelerating discoveries in the field of genetics and molecular biology.

For researchers, clinicians, and pharmaceutical developers, the value of TCIM Gene Knockout Cell Lines lies in their ability to streamline experimental workflows and provide deeper insights into gene functionality. These tools are essential for advancing our understanding of genetic influences on health and disease, paving the way for innovative therapeutic approaches.

With years of expertise in developing cutting-edge biological products, our company remains at the forefront of gene editing technology, ensuring that our TCIM Gene Knockout Cell Lines meet the highest standards of quality and performance for the research community.

Please note that all services are for research use only. Not intended for any clinical use.

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