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TCF7L1 Knockout Cell Lines

Gene: TCF7L1

Official Full Name: transcription factor 7 like 1provided by HGNC

Gene Summary: This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11657 TCF7L1 Knockout cell line (HCT 116) Human TCF7L1 1:2~1:4 Negative Online Inquiry
KO11658 TCF7L1 Knockout cell line (HEK293) Human TCF7L1 1:3~1:6 Negative Online Inquiry
KO11659 TCF7L1 Knockout cell line (A549) Human TCF7L1 1:3~1:4 Negative Online Inquiry

Background

TCF7L1 Gene Knockout Cell Lines are genetically engineered cellular models that contain targeted disruptions in the TCF7L1 gene, which is crucial in various biological processes including cell signaling and gene expression regulation through the Wnt signaling pathway. This gene plays a vital role in embryonic development and the maintenance of stem cell populations, making these knockout cell lines significant for understanding its functional relevance.

The primary mechanism of action in TCF7L1 knockout cells involves the abolition of TCF7L1-mediated transcriptional modulation, which subsequently influences downstream gene expression profiles and cellular responses. By disrupting TCF7L1 function, researchers can investigate alterations in cellular behaviors such as proliferation, differentiation, and apoptosis, as well as explore the gene's involvement in various pathologies, including cancer and metabolic disorders.

The scientific importance of TCF7L1 Gene Knockout Cell Lines is profound, as they serve as an essential tool in basic research and translational studies. In a clinical setting, these cell lines can assist in drug discovery processes and the development of therapeutic strategies targeting the Wnt signaling pathway. Furthermore, researchers can utilize these models to elucidate the role of TCF7L1 in disease mechanisms, enabling more precise interventions.

What sets our TCF7L1 Gene Knockout Cell Lines apart from alternatives is the high specificity and efficiency of the gene knockout process that we employ. Our proprietary methodology ensures robust and reproducible results, minimizing the possibility of off-target effects typically associated with conventional gene editing techniques. This unique approach allows researchers to generate reliable data, enhancing experimental validity.

For researchers, clinicians, and pharmaceutical developers seeking to deepen their understanding of gene function and develop novel treatments, TCF7L1 Gene Knockout Cell Lines offer exceptional value, promoting innovative research in areas that could lead to breakthrough therapeutic advances. With years of expertise in creating and optimizing cellular models, our company is committed to providing high-quality biological products that empower scientific discovery and lead to new clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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