Gene: TCEA2
Official Full Name: transcription elongation factor A2provided by HGNC
Gene Summary: The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35122 | TCEA2 Knockout cell line (HeLa) | Human | TCEA2 | 1:3~1:6 | Negative | Online Inquiry |
KO35123 | TCEA2 Knockout cell line (HCT 116) | Human | TCEA2 | 1:2~1:4 | Negative | Online Inquiry |
KO35124 | TCEA2 Knockout cell line (HEK293) | Human | TCEA2 | 1:3~1:6 | Negative | Online Inquiry |
KO35125 | TCEA2 Knockout cell line (A549) | Human | TCEA2 | 1:3~1:4 | Negative | Online Inquiry |
TCEA2 Gene Knockout Cell Lines are specialized cellular models designed for the study of TCEA2, a gene known to influence various critical cellular processes, including gene expression, cell proliferation, and DNA repair mechanisms. These cell lines are engineered using CRISPR-Cas9 technology to create precise deletions in the TCEA2 gene, allowing researchers to investigate the functional consequences of TCEA2 loss in a controlled environment.
The primary mechanism of action involves the introduction of targeted mutations that disrupt the gene’s normal function. This knockout model serves as an invaluable tool for dissecting the role of TCEA2 in pathophysiological contexts, including its potential involvement in cancer, developmental disorders, and cellular response to stress. By comparing TCEA2-deficient cells to wild-type controls, researchers gain insights into the molecular pathways affected by TCEA2 modulation, thereby elucidating the gene’s biological significance.
The scientific importance of TCEA2 Gene Knockout Cell Lines lies in their versatility and applicability in both research and clinical settings. They facilitate high-throughput screening for drug discovery, biomarker identification, and therapeutic target validation. Additionally, these cell lines can be utilized in gene therapy research, where understanding gene function is paramount to developing effective interventions.
Compared to alternative models, TCEA2 Gene Knockout Cell Lines offer enhanced specificity and reliability, reducing the likelihood of off-target effects commonly seen in other genetic manipulation techniques. The established knockout lines provide consistent phenotypic readouts that can expedite project timelines and optimize resource allocation.
For researchers and clinicians, the value of TCEA2 Gene Knockout Cell Lines cannot be overstated. They not only allow for deeper insights into fundamental biological processes but also contribute to the advancement of personalized medicine approaches where TCEA2 could serve as a novel therapeutic target.
Our company specializes in the development of cutting-edge biological products, leveraging our expertise in genetic engineering to provide researchers with the tools necessary for their groundbreaking work. With a commitment to scientific excellence and innovation, we ensure that our products meet the highest standards, supporting the scientific community's quest for knowledge and advancement.
Please note that all services are for research use only. Not intended for any clinical use.
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