Home / TBXAS1 Knockout Cell Lines

TBXAS1 Knockout Cell Lines

Gene: TBXAS1

Official Full Name: thromboxane A synthase 1provided by HGNC

Gene Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35116 TBXAS1 Knockout cell line (HeLa) Human TBXAS1 1:3~1:6 Negative Online Inquiry
KO35117 TBXAS1 Knockout cell line (HCT 116) Human TBXAS1 1:2~1:4 Negative Online Inquiry
KO35118 TBXAS1 Knockout cell line (HEK293) Human TBXAS1 1:3~1:6 Negative Online Inquiry
KO35119 TBXAS1 Knockout cell line (A549) Human TBXAS1 1:3~1:4 Negative Online Inquiry

Background

TBXAS1 Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the expression of the thromboxane synthase-1 (TBXAS1) gene. This gene encodes an enzyme crucial for converting prostaglandin H2 into thromboxane A2, a potent vasoconstrictor and platelet-aggregating agent involved in various physiological and pathological processes, including cardiovascular diseases and inflammatory responses. The knockout of the TBXAS1 gene allows researchers to dissect the role of thromboxane signaling in cellular mechanisms and understand its contributions to disease states.

These cell lines function as invaluable tools for studying the effects of thromboxane A2 in various biological contexts, such as vascular biology, hemostasis, and inflammation. By creating a controlled genetic context, researchers can examine the impact of TBXAS1 deficiency on cellular responses, signaling pathways, and overall cell physiology. Furthermore, these models facilitate drug screening and the assessment of potential therapeutics that target thromboxane pathways.

The scientific importance of TBXAS1 Gene Knockout Cell Lines extends to both basic research and clinical applications. In research settings, these models enable the exploration of the role of thromboxane A2 in thrombosis, atherosclerosis, and other cardiovascular diseases, informing the development of new therapeutic strategies. Clinically, understanding the functions and implications of TBXAS1 can lead to advancements in personalized medicine approaches for treating thromboxane-related disorders.

What sets TBXAS1 Gene Knockout Cell Lines apart from alternative models is their precision and specificity in eliminating the target gene, accruing high-value datasets in a short timeframe. Compared to traditional pharmacological methods that might yield off-target effects, these knockout models provide a clear genetic basis for experimental results, enhancing data relevance and reliability.

For researchers, clinicians, and biotechnology firms, investing in TBXAS1 Gene Knockout Cell Lines means accessing a powerful tool that streamlines experimental frameworks while paving the way for innovative research. Our company specializes in providing high-quality genetic models and cellular systems that demonstrate our commitment to advancing biomedical science through precise genetic engineering. By choosing our products, you are equipping your research endeavors with exceptional resources designed to unlock novel insights in the biological sciences.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.