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TBC1D5 Knockout Cell Lines

Gene: TBC1D5

Official Full Name: TBC1 domain family member 5provided by HGNC

Gene Summary: Enables AP-2 adaptor complex binding activity and retromer complex binding activity. Involved in several processes, including macroautophagy; positive regulation of receptor internalization; and retrograde transport, endosome to Golgi. Located in several cellular components, including Atg1/ULK1 kinase complex; autophagosome; and cytoplasmic vesicle membrane. Part of retromer complex. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00446 TBC1D5 knockout cell line (HeLa) Human TBC1D5 1:3~1:6 Negative Online Inquiry
KO32770 TBC1D5 Knockout cell line (HCT 116) Human TBC1D5 1:2~1:4 Negative Online Inquiry
KO32771 TBC1D5 Knockout cell line (HEK293) Human TBC1D5 1:3~1:6 Negative Online Inquiry
KO32772 TBC1D5 Knockout cell line (A549) Human TBC1D5 1:3~1:4 Negative Online Inquiry

Background

TBC1D5 Gene Knockout Cell Lines are genetically engineered cell lines that have been selectively inactivated for the TBC1D5 gene, a critical regulator of vesicular trafficking and cellular signaling pathways. By employing CRISPR-Cas9 technology, these cell lines facilitate comprehensive studies into the biological functions associated with TBC1D5, including its role in intracellular transport, endosomal recycling, and potential implications in cancer progression and metabolism.

The key function of the TBC1D5 knockout cell lines lies in their ability to elucidate the gene's impact on cellular processes. When TBC1D5 is disrupted, researchers can observe alterations in Rab GTPase activity, which is pivotal in vesicle transport and fusion. This functional knockout enables scientists to investigate downstream pathways influenced by TBC1D5, providing insights into cellular homeostasis and disease mechanisms.

In research and clinical settings, these knockout cell lines serve as invaluable tools for identifying new therapeutic targets, screening drug efficacy, and understanding the molecular underpinnings of various diseases. Their application extends across numerous fields, including oncology, neurobiology, and infectious disease research, thereby broadening the scope of potential discoveries and innovations.

Compared to standard wild-type cell lines, TBC1D5 gene knockout cell lines offer unique advantages such as increased specificity in studies of vesicular trafficking and reduced background noise in experimental results. Additionally, the use of knockout models can lead to more definitive conclusions regarding gene function and interaction, making them advantageous for both academic research and pharmaceutical development.

The value of TBC1D5 Gene Knockout Cell Lines lies not only in their ability to advance understanding of cellular mechanisms but also in their potential to pave the way for novel therapeutic strategies. Researchers and clinicians benefit from the precision and reliability these models provide, allowing for targeted investigations that are crucial in the quest for new treatments.

As a leader in the field of genetic engineering and cell line development, our company has a proven track record of delivering high-quality, innovative products tailored to meet the needs of the scientific community, ensuring that researchers have access to tools that enhance their ability to drive discovery and advancement in biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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