Gene: TBC1D2
Official Full Name: TBC1 domain family member 2provided by HGNC
Gene Summary: Enables GTPase activator activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO13559 | TBC1D2 Knockout cell line (HeLa) | Human | TBC1D2 | 1:3~1:6 | Negative | Online Inquiry |
KO13560 | TBC1D2 Knockout cell line (HCT 116) | Human | TBC1D2 | 1:2~1:4 | Negative | Online Inquiry |
KO13561 | TBC1D2 Knockout cell line (HEK293) | Human | TBC1D2 | 1:3~1:6 | Negative | Online Inquiry |
KO13562 | TBC1D2 Knockout cell line (A549) | Human | TBC1D2 | 1:3~1:4 | Negative | Online Inquiry |
TBC1D2 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the expression of the TBC1D2 gene, which encodes for a protein involved in the regulation of intracellular vesicle trafficking and membrane dynamics. These knockout cell lines are invaluable tools for investigating the functional role of TBC1D2 in various cellular processes, including autophagy, endocytosis, and signal transduction pathways.
The functionality of the TBC1D2 Gene Knockout Cell Lines stems from the precise CRISPR/Cas9 gene-editing technology employed to create these lines, enabling researchers to study the effects of TBC1D2 depletion on cellular behavior in a controlled manner. By elucidating the mechanisms by which TBC1D2 influences cellular functions, scientists can identify the molecular pathways impacted by its absence, potentially leading to breakthroughs in understanding diseases where vesicle trafficking is disrupted.
The scientific importance of TBC1D2 Gene Knockout Cell Lines lies in their broad applicability in research and clinical settings. They provide an essential model for the study of metabolic disorders, neurodegeneration, and cancer, where vesicle transport plays a crucial role. Furthermore, these cell lines facilitate high-throughput screening for drug discovery, allowing for the identification of therapeutic agents that could modulate the pathways affected by TBC1D2.
Compared to alternative models such as wild-type cell lines, TBC1D2 Knockout Cell Lines offer the unique advantage of directly assessing the loss-of-function effects specific to TBC1D2 without the confounding influences of gene expression. This specificity enhances the validity of experimental results and drives more reliable conclusions regarding the gene’s role.
For researchers and clinicians aiming to push the boundaries of current understanding in cell biology and therapeutics, TBC1D2 Gene Knockout Cell Lines represent a highly valuable resource. Our company is dedicated to providing precision-engineered biological products, backed by a team of experts committed to enhancing research capabilities and accelerating scientific discovery.
Please note that all services are for research use only. Not intended for any clinical use.
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