Gene: TANC1
Official Full Name: tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1provided by HGNC
Gene Summary: Predicted to be involved in regulation of postsynapse organization. Predicted to act upstream of or within dendritic spine maintenance; myoblast fusion; and visual learning. Predicted to be located in several cellular components, including axon terminus; neuronal cell body; and postsynaptic density. Predicted to be active in glutamatergic synapse and postsynaptic density, intracellular component. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO24203 | TANC1 Knockout cell line (HeLa) | Human | TANC1 | 1:3~1:6 | Negative | Online Inquiry |
KO24204 | TANC1 Knockout cell line (HCT 116) | Human | TANC1 | 1:2~1:4 | Negative | Online Inquiry |
KO24205 | TANC1 Knockout cell line (HEK293) | Human | TANC1 | 1:3~1:6 | Negative | Online Inquiry |
KO24206 | TANC1 Knockout cell line (A549) | Human | TANC1 | 1:3~1:4 | Negative | Online Inquiry |
TANC1 Gene Knockout Cell Lines represent an innovative tool in molecular biology, specifically engineered to facilitate the study of TANC1 gene functions by eliminating its expression in cultured cells. TANC1, or Tetratricopeptide-Repeat and Ankyrin-Repeat Motif 1, is implicated in various cellular processes, including signal transduction and cellular differentiation. By using these knockout cell lines, researchers can effectively investigate the role of the TANC1 gene in diverse biological pathways, offering a clear advantage in studying gene function in a controlled environment.
The principal mechanism by which TANC1 Gene Knockout Cell Lines operate involves the application of CRISPR-Cas9 technology, which introduces precise mutations that disrupt the gene's coding sequence, leading to a null phenotype. This targeted gene disruption not only elucidates the contributions of TANC1 to cellular behavior but also aids in understanding its association with various diseases, thus expanding the possibilities for therapeutic interventions.
In terms of scientific importance, these knockout cell lines play a crucial role in both basic and applied research settings. They are invaluable for investigating how TANC1 influences processes such as tumorigenesis, neurodevelopment, and synaptic plasticity, making them essential for research in cancer biology, neurobiology, and more. Clinically, they can serve as models for drug screening and genetic disease studies, therefore having profound implications for treatment strategies.
Compared to alternative cell line models, TANC1 Gene Knockout Cell Lines offer unparalleled specificity and reliability. They reduce the risk of off-target effects, thereby ensuring that observed phenotypes can be directly attributed to the TANC1 gene. Moreover, these cell lines are compatible with various high-throughput assays and can be easily manipulated for downstream applications.
For researchers and clinicians looking to deepen their understanding of cellular mechanisms or to develop targeted therapies, the TANC1 Gene Knockout Cell Lines are an indispensable resource. They simplify experimental designs and enhance the accuracy of research outcomes, enabling users to push the boundaries of biological discovery.
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Please note that all services are for research use only. Not intended for any clinical use.
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