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TAF9B Knockout Cell Lines

Gene: TAF9B

Official Full Name: TATA-box binding protein associated factor 9bprovided by HGNC

Gene Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is similar to one of the small subunits of TFIID, TBP-associated factor 9, and is also a subunit of TFIID. TAF9 and TAF9b share some functions but also have distinct roles in the transcriptional regulatory process. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO22371 TAF9B Knockout cell line (HeLa) Human TAF9B 1:3~1:6 Negative Online Inquiry
KO22372 TAF9B Knockout cell line (HCT 116) Human TAF9B 1:2~1:4 Negative Online Inquiry
KO22373 TAF9B Knockout cell line (HEK293) Human TAF9B 1:3~1:6 Negative Online Inquiry
KO22374 TAF9B Knockout cell line (A549) Human TAF9B 1:3~1:4 Negative Online Inquiry

Background

TAF9B Gene Knockout Cell Lines are genetically modified human cell lines in which the TAF9B gene has been disrupted through targeted gene knockout techniques, such as CRISPR-Cas9 technology. The TAF9B gene encodes a crucial component of the TFIID complex, which is essential for the transcription of protein-coding genes. By creating knockout models, researchers can study the functional implications of loss-of-function mutations in TAF9B, elucidating its role in various biological processes, including gene expression regulation, cell proliferation, and differentiation.

The primary function of the TAF9B knockout cell lines is to serve as a powerful tool for examining the central roles of TAF9B in development and disease pathways, specifically cancer and genetic disorders. By utilizing these cell lines, researchers can investigate alterations in transcriptional activity, cellular signaling pathways, and the cellular response to environmental stimuli. The mechanistic insights gained from these studies can significantly advance our understanding of the contributions of TAF9B to both normal cellular functions and pathological conditions.

The scientific importance of TAF9B Gene Knockout Cell Lines extends to their applications in basic research, target validation for drug development, and mechanistic studies in clinical pathology. Moreover, these cell lines provide a robust framework for investigating gene therapy approaches and functional assays in context-specific models, facilitating the identification of novel therapeutic targets and biomarkers.

What distinguishes our TAF9B Gene Knockout Cell Lines from other alternatives is the precision with which the gene disruption is performed, ensuring reproducibility and reliability in experimental outcomes. Additionally, our comprehensive validation processes allow for the identification of off-target effects, providing confidence in the interpretation of results.

By choosing TAF9B Gene Knockout Cell Lines, researchers and clinicians gain access to a state-of-the-art resource that enhances their capacity to dissect complex biological questions and translates their discoveries into impactful clinical applications. Our company is committed to advancing biological research through the provision of high-quality genetic models, backed by an experienced team dedicated to supporting the scientific community.

Please note that all services are for research use only. Not intended for any clinical use.

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