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TAF11 Knockout Cell Lines

Gene: TAF11

Official Full Name: TATA-box binding protein associated factor 11provided by HGNC

Gene Summary: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit of TFIID that is present in all TFIID complexes and interacts with TBP. This subunit also interacts with another small subunit, TAF13, to form a heterodimer with a structure similar to the histone core structure. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04277 TAF11 Knockout cell line (HeLa) Human TAF11 1:3~1:6 Negative Online Inquiry
KO04278 TAF11 Knockout cell line (HCT 116) Human TAF11 1:2~1:4 Negative Online Inquiry
KO04279 TAF11 Knockout cell line (HEK293) Human TAF11 1:3~1:6 Negative Online Inquiry
KO04280 TAF11 Knockout cell line (A549) Human TAF11 1:3~1:4 Negative Online Inquiry

Background

TAF11 Gene Knockout Cell Lines are specialized biological tools developed for advanced cellular and molecular research. These cell lines are engineered to lack the TAF11 gene, which encodes a crucial subunit of the TFIID transcription factor complex that is integral to the transcriptional regulation of RNA polymerase II. By eliminating TAF11, researchers can study the downstream effects on gene expression, transcriptional control, and cellular processes, thereby providing insights into the regulatory networks that govern cellular function.

The primary mechanism through which TAF11 knockout exerts its influence is by disrupting normal transcriptional activity, leading to observable phenotypic changes in targeted cells. This disruption allows researchers to explore the gene's role in various biological contexts, including differentiation, cellular response to stress, and cancer progression. Such insights are invaluable in both basic research and translational studies, as they pave the way for understanding the implications of transcriptional dysregulation in human diseases.

In clinical settings, these knockout cell lines hold great promise for drug discovery and testing, particularly in identifying novel therapeutic targets that modulate gene expression pathways affected by TAF11. Compared to traditional knockdown approaches (such as siRNA), knockout models provide a more definitive and stable alteration of gene function, thus presenting a more relevant and reproducible experimental framework.

The specific advantages of TAF11 Gene Knockout Cell Lines lie in their precision and reliability. Users can expect consistent performance and clear results, which are critical for high-stakes research applications. Additionally, these cell lines are compatible with a variety of assays, making them versatile tools for researchers seeking to elucidate complex biological questions.

Establishing a foundation in rigorous scientific expertise, our company is dedicated to providing high-quality biological products tailored for innovative research. With our commitment to advancing scientific understanding, TAF11 Gene Knockout Cell Lines represent a pivotal addition to any laboratory focused on gene regulation studies and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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