Gene: SYP
Official Full Name: synaptophysinprovided by HGNC
Gene Summary: This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02372 | SYP Knockout cell line (HCT 116) | Human | SYP | 1:2~1:4 | Negative | Online Inquiry |
KO02373 | SYP Knockout cell line (HEK293) | Human | SYP | 1:3~1:6 | Negative | Online Inquiry |
KO02374 | SYP Knockout cell line (A549) | Human | SYP | 1:3~1:4 | Negative | Online Inquiry |
SYP Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate the study of synaptophysin (SYP), a critical protein involved in synaptic neurotransmitter release. These cell lines have been genetically modified to delete the SYP gene, allowing researchers to elucidate the molecular mechanisms underlying synaptic function and dysfunction. By eliminating SYP expression, these cell lines serve as a vital tool for investigating the roles of synaptic proteins in neurological diseases and dynamic neuronal interactions.
The key mechanism of action of the SYP Gene Knockout Cell Lines involves targeted CRISPR-Cas9 gene editing technology, which enables precise deletions at the genomic level. This ensures the complete absence of the SYP protein, permitting researchers to draw clear conclusions about the protein’s contribution to neuronal activity and synaptic integrity. The knockout model provides a unique environment to study the downstream effects of SYP loss, including changes in synaptic vesicle dynamics and neurotransmitter release profiles.
Scientifically, SYP Gene Knockout Cell Lines are invaluable for both basic research and clinical applications. They enable scientists to probe the roles of synaptic proteins in models of neurodegenerative diseases, psychiatric disorders, and synaptic plasticity. By providing insights into SYP-related pathways, these models support the discovery and development of potential therapeutic targets aimed at restoring normal synaptic function.
Compared to conventional models, such as wild-type cell lines, SYP Gene Knockout Cell Lines offer distinct advantages, including a clear genetic background and a controlled study environment that enhances reproducibility and reliability of data. Researchers benefit from the streamlined analysis of synaptic dysfunction, making these cell lines a superior choice for advancing neuroscience research.
The value of SYP Gene Knockout Cell Lines extends beyond academic research; they are a critical resource for clinicians and biopharmaceutical companies targeting synaptic pathology. The ability to model various neurological conditions at the molecular level empowers innovative therapeutic strategies.
Our company prides itself on being at the forefront of genetic engineering technology and providing high-quality biological products tailored to meet the challenging needs of researchers and clinicians alike. With our expertise, we are committed to facilitating groundbreaking discoveries in the field of neuroscience through precision tools like the SYP Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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