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SYNE4 Knockout Cell Lines

Gene: SYNE4

Official Full Name: spectrin repeat containing nuclear envelope family member 4provided by HGNC

Gene Summary: This gene is a member of the nesprin family of genes, that encode KASH (Klarsicht, Anc-1, Syne Homology) domain-containing proteins. In addition to the KASH domain, this protein also contains a coiled-coil and leucine zipper region, a spectrin repeat, and a kinesin-1 binding region. This protein localizes to the outer nuclear membrane, and is part of the linker of nucleoskeleton and cytoskeleton (LINC) complex in the nuclear envelope. LINC complexes are formed by SUN (Sad1, UNC-84)-KASH pairs, and are thought to mechanically couple nuclear components to the cytoskeleton. Mutations in this gene have been associated with progressive high-frequency hearing loss. The absence of this protein in mice also caused hearing loss, and changes in hair cell morphology in the ears. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]

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Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO13611 SYNE4 Knockout cell line (HCT 116) Human SYNE4 1:2~1:4 Negative Online Inquiry

Background

SYNE4 Gene Knockout Cell Lines are specialized cellular models that have been genetically engineered to ablate the expression of the SYNE4 gene. This gene, which encodes a protein involved in the organization of the cytoskeleton and maintenance of nuclear architecture, plays a critical role in various cellular functions. By precisely knocking out this gene, researchers can gain insights into its biological functions and the pathways it influences, thereby elucidating its contribution to normal cellular physiology and disease states.

The mechanisms underlying the functionality of SYNE4 Gene Knockout Cell Lines involve targeted genome editing technologies, such as CRISPR-Cas9, which enable the specific disruption of the SYNE4 gene. This allows for a clearer understanding of SYNE4's role in cellular processes such as cell migration, proliferation, and response to mechanical stimuli. The knockout models serve as invaluable tools in both basic and applied research, facilitating investigations into cancer biology, neuromuscular disorders, and other conditions where cytoskeletal dynamics and nuclear positioning are paramount.

From a scientific perspective, the SYNE4 Gene Knockout Cell Lines hold significant promise in translational research and drug discovery, enabling clinicians and researchers to investigate therapeutic targets and biomarkers linked to diseases influenced by cytoskeletal dysfunction. These cell lines provide a unique platform for high-throughput screening of chemical libraries and the development of novel therapeutic agents.

What sets SYNE4 Gene Knockout Cell Lines apart from traditional wild-type cell lines is the specificity and efficiency of the gene disruption. This targeted approach minimizes off-target effects and ensures consistent results that can be replicated across studies. Furthermore, the availability of these knockout models allows researchers to accelerate their work, reducing the time from hypothesis to experimental validation.

In today's rapidly evolving research environment, these cell lines represent a critical resource for scientists seeking to unravel complex biological mechanisms and develop innovative interventions. Our company, with a strong foundation in genetic engineering and cell biology, prides itself on delivering high-quality and reliable biological products tailored to meet the rigorous demands of the scientific community. With our expertise, researchers can confidently explore the functional impacts of the SYNE4 gene knockout, ultimately contributing to advancements in biomedical research and therapeutic development.

Please note that all services are for research use only. Not intended for any clinical use.

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